The relationships between arterial pressure (BP) and plasma vasopressin levels, plasma renin activity, and other variables were determined in 96 untreated essential hypertensive men (146/100 mm Hg) and women (153/102 mm Hg) whose average age was 44 years, 80 normal men and women (121/79 mm Hg; mean age, 47 +/- 2 years), and 40 subjects defined as borderline hypertensive. An analysis of variance...

The aim of this study was to examine whether control of vascular resistance by vagal afferents is altered in the early as well as late stage of hypertension. We examined the effects of vagotomy on hindlimb vascular resistance as well as on arterial baroreflex control of hindlimb vascular resistance in spontaneously hypertensive rats and Wistar-Kyoto rats, 12 and 35 weeks old. Vagotomy in rats w...

The aim of this study was to examine whether control of vascular resistance by vagal afferents is altered in the early as well as late stage of hypertension. We examined the effects of vagotomy on hindlimb vascular resistance as well as on arterial baroreflex control of hindlimb vascular resistance in spontaneously hypertensive rats and Wistar-Kyoto rats, 12 and 35 weeks old. Vagotomy in rats w...

OBJECTIVE To evaluate the additional value of funduscopy in the routine management of patients with hypertension. DESIGN Systematic review. PARTICIPANTS Adults aged 19 or more with hypertensive retinopathy. DATA SOURCES Medline, Embase, and the Cochrane Library from 1990. REVIEW METHODS Studies were included that assessed hypertensive retinopathy with blinding for blood pressure and car...

The uptake and content of serotonin in blood platelets were studied in patients with essential hypertension and in five families in which at least one member was hypertensive. Blood was obtained from male and female normotensive volunteers and hypertensive patients who were free of medication. Lineweaver-Burk plots of 3H-serotonin uptake from both control subjects and hypertensive patients were...

Newborn male rats from the New Zealand colony with genetic hypertension (hypertensive rats) and from a normotensive colony (controls) were immunosympathectomized by injections of antiserum to nerve growth factor. Blood pressure of immunosympathectomized hypertensive rats aged 63 days (128±2 mm Hg) was significantly less (P<.001) than that of untreated hypertensive rats (176 ± 3 mm Hg) of the sa...

Although one of the common characteristics of pulmonary hypertension is abnormal sustained vasoconstriction, the signaling pathways that mediate this heightened pulmonary vascular response are still not well defined. Protein kinase C (PKC) and Rho-kinase are regulators of smooth muscle contraction induced by G protein-coupled receptor agonists including endothelin-1 (ET-1), which has been impli...

The present study aims to examine the genetic variation of ATP1B1 gene concerning hypertension and chronic kidney disease CKD. (120 ) blood samples from participants were obtained divided into three groups: a first group representing hypertensive patients (hyper), second Hypertensive CKD (hyper with CKD), third control group. DNA was extracted all then converted cDNA ARMS-PCR technique used inv...