T H E skeleton of young animals is profoundly affected by an abnormal amount of vitamin A in the body. In vitamin A deficiency changes in the functional activity of the osteoblasts and osteoclasts allow bone to be deposited in places where it would normally be removed, so producing excessive thickening of certain parts of the skeleton (Mellanby, 1938, 1939). Conversely, excessive vitamin A caus...

Vitamin A is normally transported in plasma as retinol bound to a specific protein, retinol-binding protein (RBP). Detailed studies were conducted to examine the effects of excess vitamin A on the plasma concentration and metabolism of RBP, and to obtain information about vitamin A transport in the hypervitaminotic state. Two separate experiments were conducted. In the first (Study I, 99 days),...

AIM To evaluate vitamin D (vitD) monitored therapy effectiveness and safety in preterm neonates. PATIENTS AND METHODS Our observational study was carried out in 80 neonates born before 33 weeks' gestational age (GA) hospitalized in the Clinical Department of Neonatology and Neonatal and Intensive Care Department Medical University of Warsaw from July 2013 to July 2014. Daily vitamin D oral su...

Breitman, T. R., Selonick. S. E. & Collins, S. J. (1980) Proc. Natl. Acad. Sci. U.S.A. 77, 2936-2940 Dawson, M. I., Hobbs, P. D., Derdzinski, K., Chan, R. L.-S., Gruber, J., Chao, W., Smith, S., Thies, R. W. & Schiff, L. J. (1984) J . Med. Chem. 27, 15161531 Frickel, F. (1984) in The Retinoih (Sporn, M. B., Roberts, A. B. & Goodman, D. S., eds.), vol. I , pp. 7-145 Academic Press, Orlando, FL F...