BACKGROUND Although hypoglycemia is the most common complication of intensive diabetes therapy, there is little information about risk factors for hypoglycemia in patients with type 2 diabetes mellitus. OBJECTIVE To determine the prevalence and predisposing factors for hypoglycemia in patients with type 2 diabetes. METHODS Retrospective, cross-sectional analysis set in an outpatient special...

Autoimmune dysglycemia syndrome (ADS) is a rare condition that presents as episodes of hypoglycemia well hyperglycemia and classified insulin autoimmune (IAS) type B resistance (TBIR). Autoimmunity plays key role in the pathogenesis this disorder, evidenced by presence autoantibodies against endogenous or receptor, its association with rheumatologic disorders. Treatment usually includes glycemi...

OBJECTIVE Little is known about the prognostic impact of hypoglycemia associated with hospitalization. We hypothesized that hospitalized hypoglycemia would be associated with increased long-term morbidity and mortality, irrespective of diabetes status. RESEARCH DESIGN AND METHODS We undertook a cohort study using linked administrative health care and laboratory databases in Alberta, Canada. F...

OBJECTIVE We tested the hypothesis that adrenergic activation, cholinergic activation, or both, mediate the effect of recent antecedent hypoglycemia to reduce the sympathoadrenal response to subsequent hypoglycemia, the key feature of hypoglycemia-associated autonomic failure in diabetes, in humans. RESEARCH DESIGN AND METHODS Seventeen healthy adults were studied on 2 consecutive days on thr...

OBJECTIVES To determine the prevalence of hypoglycemia in critically ill nondiabetic children and the association of hypoglycemia with mortality and worsening organ function in critically ill children. DESIGN Retrospective cohort study with matched-cohort analysis. SETTING Academic pediatric intensive care unit. PATIENTS A total of 899 nondiabetic patients <18 yrs old admitted to the pedi...

With unwarranted enthusiasm, the popular press has embraced hypoglycemia as an explanation for a host of physical ailments. Although this has permitted purveyors of numerous "treatments" to do a brisk business, very little helpful and accurate information has been communicated about hypoglycemia. Lynn Bennion, a Stanford-based clinician, has written a book that provides the general public acces...

OBJECTIVE Patients may fear the symptoms and consequences associated with hypoglycemia. We tested whether fear of hypoglycemia is independently associated with poorer health-related quality of life (HRQOL). RESEARCH DESIGN AND METHODS Data were collected using direct-mail survey and enrollment information from adult commercial health plan enrollees with type 2 diabetes during a 12-month perio...

Hypoglycemia has a serious impact on the morbidity, mortality and quality of life people with Diabetes Mellitus (DM). To prevent or reduce risk hypoglycemia, education is very important, including identification detection causes, prevention efforts early treatment at home. The use mobile applications strongly supports independent health management because it easily accessible, portable, low cos...

Glasgow et al reported a cost-utility analysis (CUA) of prophylactic dextrose gel compared with standard care for neonatal hypoglycemia in at-risk infants. 1 M.J. Edlin R. Harding J.E. Cost-utility vs J Pediatr. 2020; 226: 80-86.e1 Abstract Full Text PDF Scopus (4) Google Scholar They found that this simple intervention not only reduced long-term morbidity and mortality, but also saved money. T...

In this issue of Diabetes, Joy et al. (1) report that in healthy individuals hyperinsulinemic hypoglycemia, compared with hyperinsulinemic euglycemia, reduced endogenous nitric oxide (NO)-mediated endothelial vasodilation, activated inflammatory processes, impaired fibrinolytic balance, and increased proatherothrombotic mechanisms and that repeated episodes of hypoglycemia on two consecutive da...