The hypoglycemic and hypolipidemic effects of flavonoid rich extract obtained from seeds of Eugenia jambolana (EJ) was analyzed in streptozotocin induced diabetic rats. Hypoglycemic activity was assessed by reduction in fasting blood glucose (FBG) and peak blood glucose level within 60 min of glucose tolerance test (GTT) in mild and severe diabetic (MD and SD respectively) rats. Different bioch...

The metabolites of N-[(trimethylamineboryl)-carbonyl]-L-phenylalanine methyl ester 1 proved to be active in a number of pharmacological screens where the parent had previously demonstrated potent activity. The proposed metabolites demonstrated significant activity as cytotoxic, hypolipidemic, and anti-inflammatory agents. In cytotoxicity screens several of the proposed metabolites afforded bett...

This study was aimed to investigate an acute toxicity and effects of Nelumbo nucifera flower extract (NNFE) on hyperglycemic and hypolipidemic effects in streptozytocin-induced diabetic rats. In vivo acute toxicity study of NNFE was carried out by once oral administration various doses (0, 500, 1000, 1500 and 2000 mg/kg) of the extract to healthy male adult Wistar rats. Sign or symptom of toxic...

The present study is designed to investigate the hypolipidemic effect of ethanolic extract from the leaves of Hibiscus sabdariffa L. (HSEE) in hyperlipidemic rats. In the present work, HSEE was evaluated at three doses (i.e. 100, 200 and 300 mg/kg, orally) in cholesterol-induced (2 g/kg, orally) hyperlipidemic Wistar rats. Atorvastatin (10 mg/kg, orally) was used as the standard drug. Administr...

Fax: +913222-282221 Abstract Context: Mangifera indica (Anacardiaceae) stem bark contains a rich content of mangiferin and is used traditionally in Indian Ayurvedic system to treat diabetes. Purpose of the study: To investigate anti-diabetic and hypolipidemic effects of mangiferin in type 1 and type 2 diabetic rats models. Streptozotocin was used to induce type 1 and type 2 diabetic rats. Mangi...

The antioxidative and hypolipidemic effects of green tea polyphenols (TP) in mice fed a fish oil-supplemented diet were investigated. Male ddY mice of 8 weeks old were given the following diets for 21 days: control diet (a diet supplemented with 5. 0% corn oil), a diet with 0. 5% corn oil and 4. 5% cod liver oil, or a diet with 0. 5% corn oil, 4. 5% cod liver oil, and 0. 5% TP. The contents of ...

Objective. To evaluate the hypolipidemic activity and antiatherosclerotic effect of polysaccharide of Polygonatum sibiricum (PPGS), which is a kind of Chinese herbal medicine using the rhizome part of the whole herb. Materials and Methods. Thirty rabbits were divided into normal control group, model control group, and PPGS subgroups of 0.8, 1.6, and 3.2 mL/kg/day under random selection. In athe...

The hypolipidemic activity of Lepidium sativum (family: Brassicaceae) seed sapogenin and flavonoid extract (LSTS and LSTF) was studied against Triton x-100 and high cholesterol diet (HCD) induced hyperlipidemia on rats. The parameters assessed were serum total protein, total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDLc), low density lipoprotein cholesterol (LD...

INTRODUCTION Hyperlipidemia is the most common form of dyslipidemia, which is the key risk factor for cardiovascular disease and stroke. The development of effective and safe drug treatments for hyperlipidemia has been proven challenging. METHODS In this study, taking advantage of the transparency of larval zebrafish, we developed a zebrafish hyperlipidemia model for drug screening and effica...