Purpose Heart Failure (HF) is one of the leading mortality causes in elderly people. The purpose this study to assess readmission rates and reasons patients with HF. Design/methodology/approach authors explored medical records HF (75 years more) at Chapidze Emergency Cardiology Center (Georgia) from 2015 2019. analyzed structure cardiovascular diseases hospitalized (I50, I50.0 I50.1). A multiva...

Cell to cell communication via gap junctions is essential in the maintenance of the homeostatic balance of multicellular organisms. Aberrant intercellular gap junctional communication (GJIC) has been implicated in tumor promotion, neuropathy and teratogenesis. Oxidative stress has also been implicated in similar pathologies such as cancer. We report a potential link between oxidative stress and...

Tissue plasminogen activator binds to endothelial cells via the calcium-regulated phospholipid-binding protein annexin II, an interaction that is inhibited by the prothrombotic amino acid homocysteine. We sought to identify the tissue plasminogen activator binding domain of annexin II and to determine the mechanism of its modulation by homocysteine. Tissue plasminogen activator binding to immob...

To assess the tolerance and phytoaccumulation ability of the duckweed Lemna gibba L. to copper (Cu) and nickel (Ni), the aquatic plants were exposed to different concentrations of Cu and Ni (0.1 – 2.0 mg/L) in quarter Coïc and Lesaint solution at pH = 6.0 (± 0.1) and under a daily regime of 12 h light. Copper and nickel were tolerated by L. gibba at concentrations ≤ 0.3 mg/L and ≤ 0.5 mg/L, res...

We investigate the structure of the strange attractor of a chaotic loss-modulated solid-state laser utilizing return maps based on a combination of intensity maxima and interspike intervals, as opposed to those utilizing Poincaré sections defined by the intensity maxima of the laser ( İ50,Ï,0) alone. We find both experimentally and numerically that a simple, intrinsic relationship exists betwee...

Drug interactions (DIs) constitute a serious problem and are considered to contribute to 6-30% of all adverse events (AEs). The use of existing data, including claims data, is expected to be helpful in detecting unknown DIs by complementing conventional spontaneous reporting systems. In the present study, an 'Ω shrinkage measure' was applied to the Korean National Health claims database to test...

In order to study the role of residue in the active site of glutathione S-transferase (GST), Arg13 residue in human GST P1-1 was replaced with alanine, lysine and leucine by site-directed mutagenesis to obtain mutants R13A, R13K and R13L. These three mutant enzymes were expressed in Escherichia coli and purified to electrophoretic homogeneity by affinity chromatography on immobilized GSH. Mutat...

Two approaches for monitoring atenolol (ATL) were applied: an immunochemical assay and a competitive-binding assay, based on the interaction between ATL and its target receptor, β1 adrenergic receptor (β1AR). Polyclonal antibodies (Abs) for ATL were generated, and a highly specific microplate immunochemical assay, that is, an enzyme-linked immunosorbent assay (ELISA), for its detection was deve...

Pancuronium causes a powerful and highly selective inhibition of human serum cholinesterase in vitro. The inhibition was studied in serum from 14 individuals of both sexes (5-60 years of age) with normal reactions to suxamethonium. Pancuronium, in a concentration of 2.3 x 10(-7) M, caused a 50% inhibition of the enzymatic hydrolysis of acetylcholine, when this substrate was present in a concen...