Infectious bursal disease virus (IBDV) is an avian pathogen responsible for an acute immunosuppressive disease that causes major losses to the poultry industry. Despite having a bipartite dsRNA genome, IBDV, as well as other members of the Birnaviridae family, possesses a single capsid layer formed by trimers of the VP2 capsid protein. The capsid encloses a ribonucleoprotein complex formed by t...

INTRODUCTION The airborne transmission of infectious diseases in livestock production is increasingly receiving research attention. Reliable techniques of air sampling are crucial to underpin the findings of such studies. This study evaluated the physical and biological efficiencies and detection limits of four samplers (Andersen 6-stage impactor, all-glass impinger "AGI-30", OMNI-3000 and MD8 ...

Marek's disease herpesvirus is a vaccine vector of great promise for chickens; however, complete protection against foreign infectious diseases has not been achieved. In this study, two herpesvirus of turkey recombinants (rHVTs) expressing large amounts of infectious bursal disease virus (IBDV) VP2 antigen under the control of a human cytomegalovirus (CMV) promoter or CMV/beta-actin chimera pro...

infectious bursal disease (ibd) is an economically important viral disease of chickens with worldwide distribution which suppresses the immune system of young chickens. vp2 is the major host-protective protein of infectious bursal disease virus (ibdv). the encoding region of vp2 protein was pcr amplified from a plasmid containing a cdna fragment of large genomic segment of ibdv, strain d78. thi...

Background Campylobacter jejuni is considered as a chicken commensal. The gut microbiota and the immune status of the host may affect its colonization. Infectious bursal disease virus (IBDV) is an immunosuppressive virus of chickens, which allows secondary pathogens to invade or exacerbates their pathogenesis. To investigate the effect of IBDV-induced immunosuppression on the pathogenesis of C....

Vaccination is an essential component in controlling infectious bursal disease (IBD), however, there a lack of information on the genetic characteristics recent virus (IBDV) that was isolated from IBD vaccinated commercial flocks Malaysia. The present study investigated 11 IBDV isolates were poultry farms. detected using reverse transcription-polymerase chain reaction (RT-PCR) targeting hyperva...

27 Infectious bursal disease (IBD) is characterized by immunosuppression due to 28 the depletion of lymphocytes in the atrophied bursa of Fabricius (BF). We have 29 sometimes encountered contradictory findings: chickens infected with the 30 vaccine IBD virus (IBDV) strain have sometimes exhibited a highly atrophied 31 BF but not immunosuppression. In this study, chickens administered vaccine or...

We developed a reverse genetics system for infectious pancreatic necrosis virus (IPNV), a prototype virus of the Birnaviridae family, with the use of plus-stranded RNA transcripts derived from cloned cDNA. Full-length cDNA clones of the IPNV genome that contained the entire coding and noncoding regions of RNA segments A and B were constructed. Segment A encodes a 106-kDa precursor protein which...

Infectious bursal disease (IBD), caused by an Avibirnavirus, belonging to the family Birnaviridae, is immunosuppressive that affects 3–6-week-old chickens, resulting in clinical or subclinical infection. Although occurs turkeys, ducks, guinea fowl, and ostriches can be also infected. IBD virus (IBDV) causes lymphoid depletion of bursa, which responsible for severe depression humoral antibody re...