Production of biofilm in Staphylococcus epidermidis is mediated through enzymes produced by the four-gene operon ica and is subject to phenotypic variation. The purpose of these experiments was to investigate the regulation of ica and icaR transcription in phenotypic variants produced by multiple unrelated isolates of S. epidermidis. Ten isolates were chosen for the study, four of which contain...

BACKGROUND AND PURPOSE Gradation of high-grade intracranial internal carotid artery (ICA) stenosis poses a challenge to noninvasive neurovascular imaging, which seems critical for angioplasty in the ICA segments C1 and C5. We investigated cutoff values of intracranial ICA stenosis for transcranial color-coded sonography (TCCS) and compared this method with the "gold standard," digital subtracti...

Icariin (ICA) is a major component isolated from Epimedium brevicornum. Emerging evidence shows that ICA can inhibit tumor cell proliferation, invasion and migration. However, the anti-cancer effect of ICA on B16 cells has not been fully investigated. Here we found that the proliferation of B16 cells was inhibited by ICA in a concentration- and time-dependent manner, and the colony formation of...

OBJECTIVE Cyclic GMP has been shown to be in some respects an inhibitory modulator of heart function. Various studies on the modulation of cardiac L-type calcium current (ICa) by cGMP in different species show inconsistency and the role of cGMP remains unclear and controversial. The present study was focused on the differences in the modulation of basal ICa by cGMP in adult and newborn rabbit v...

Independent component analysis (ICA) has become an increasingly utilized approach for analyzing brain imaging data. In contrast to the widely used general linear model (GLM) that requires the user to parameterize the data (e.g. the brain's response to stimuli), ICA, by relying upon a general assumption of independence, allows the user to be agnostic regarding the exact form of the response. In ...

BACKGROUND Although extracranial internal carotid artery (e-ICA) occlusion is a common pathology in patients undergoing intravenous thrombolysis for treatment of acute ischemic stroke, no data on e-ICA recanalization rate or potential effects on outcome are yet available. METHODS AND RESULTS This study included 52 consecutive patients with e-ICA occlusion and ischemic stroke undergoing standa...

BACKGROUND AND PURPOSE Internal carotid artery (ICA) aneurysms may present with cranial nerve dysfunction. Therapeutic ICA occlusion, when tolerated, is an effective treatment resulting in improvement or cure of symptoms in most patients. When ICA occlusion is not tolerated, selective endovascular aneurysm occlusion can be considered. We compare recovery of cranial nerve dysfunction in patients...

EEG signals may be affected by physiological and non-physiological artifacts hindering the analysis of brain activity. Blind source separation methods such as independent component (ICA) are effective ways improving signal quality removing components representing non-brain However, most ICA-based artifact removal strategies have limitations, individual differences in visual assessment component...

Principal component analysis (PCA) and independent component analysis (ICA) are both based on a linear model of multivariate data. They are often seen as complementary tools, PCA providing dimension reduction and ICA separating underlying components or sources. In practice, a two-stage approach is often followed, where first PCA and then ICA is applied. Here, we show how PCA and ICA can be seen...

We propose a new Single-Input Multiple-Output (SIMO)-modelbased ICA with information-geometric learning algorithm for highfidelity blind source separation. The SIMO-ICA consists of multiple ICAs and a fidelity controller, and each ICA runs in parallel under the fidelity control of the entire separation system. The SIMOICA can separate the mixed signals, not into monaural source signals but into...