&&v,w To assess the penetration of Iossrtan and L-158,338 into the rabbit eye after topical application and their effects on the IOP of ocular hypertensive cynomolgus monkeys. M&Q& Penetration was indirectly assessed in albino rabbits using an & assay. Aliquots of aqueous humor were sampled one hour after the bilateral topical instillation of one drop (50 uL) of 2% solutions of losartsn or L-15...

The ultra-rapid satellite clock product based on the batch estimation is commonly used for high-precision and reliable precise point positioning (PPP) services. In order to clarify effect of different ranging errors accuracy, source bias induced by observation model classified into initial (ICB) time-dependent (TDB). addition ICB TDB, analytic relationship between redundancy accuracy are derive...

Camera motion introduces spatially varying blur due to the depth changes in 3D world. This work investigates scene configurations where such is produced under parallax camera motion. We present a simple, yet accurate, Image Compositing Blur (ICB) model for depth-dependent blur. The (forward) produces realistic from single image, map, and trajectory. Furthermore, we utilize ICB model, combined w...

After IRB approval, we retrospectively reviewed the regional anesthesia database of one staff anesthesiologist (ERM) from a university hospital outpatient surgery center collected over one year as part of an ongoing quality assurance (QA) project. Data from patients who received perivascular AXB or coracoid ICB were included. Nerve blocks were performed preoperatively using sterile technique in...

Awareness of memory deficits is useful to distinguish between depression and mild cognitive impairment in the elderly Gabriel Coutinho, Cláudia Drummond, Alina Teldeschi, Paulo Mattos Instituto D’Or de Pesquisa e Ensino (IDOR), Rio de Janeiro, RJ, Brazil. Programa de Ciências Morfológicas (PCM), Instituto de Ciências Biomédicas (ICB), Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeir...

Abstract Background Colorectal cancer (CRC) infiltration by T lymphocytes is associated with prolonged survival. However, immune spontaneously occurs in <20% of tumors and no therapies able to promote it are currently available. CRC tissue populated gut bacteria translocated across the neoplastic epithelium. We previously showed that direct contact between tumor cells induces overexpress...

Gut microbiota modulates the response to immune checkpoint blockade (ICB) in various cancers, and diet represents most natural non-evasive method shift its composition. A recent study suggests that a high dietary fiber intake may improve progression-free survival (PFS) of melanoma patients treated with ICB. However, impact on advanced non-small cell lung cancer (NSCLC) has not been yet investig...

Hybrid dc circuit breakers (HCBs) are recognized as suitable devices for protecting high-voltage direct-current (HVDC) systems, along with other (DCCB). However, compared to mechanical breakers, HCBs exhibit higher conduction losses. Such losses inevitable under no-fault conditions current may flow through some of the semiconductor switches. An integrated breaker (ICB) minimizing these is prese...