BACKGROUND Bisphosphonates‎ inhibit osteoclasts, prevent bone resorption and decrease bone turnover. This study examined radiography finding in bisphosphonate-associated osteonecrosis of jaws. MATERIALS AND METHODS This is a retrospective series of 12 clinically diagnosed patients between 7 to 21 year old (average 13 years). They required emergency dental conditions requiring management by de...

recommended the use of the name primary myelofibrosis (PMF) for the clinicopathologic entity otherwise known as chronic idiopathic myelofibrosis, agnogenic myeloid metaplasia, or myelofibrosis with myeloid metaplasia. The deliberations of the expert panel took into account the fact that the key pathogenetic process in PMF is no longer idiopathic or agnogenic; PMF is now known to constitute a cl...

idiopathic cd4+ lymphocytopenia is a rare combined immunodeficiency disease, characterized by low cd4+ t-cell count and increased susceptibility to opportunistic infections, autoimmunity and malignancies after exclusion of secondary forms of cd4 lymphocytopenia. here we present a 13-year old boy who was referred to our center because of destructive ulceration of soft and hard palates with exten...

materials and methods a number of 100 patients with imr, normal karyotypes and negative fragile-x and metabolic tests were screened for subtelomeric abnormalities using mlpa technique. results nine of 100 patients showed subtelomeric abnormalities with at least one of the two mlpa kits. deletion in a single region was found in 3 patients, and in two different subtelomeric regions in 1 patient. ...

Erdheim-Chester disease (ECD) is a rare, xanthogranulomatous, non-Langerhans cell histiocytosis with frequent systemic involvement. Although the diagnosis is based on characteristic histological and radiological findings, its identification can be challenging because of its heterogeneous presentation. Osteosclerosis of long bones, often associated with bone pain, is the most common initial mani...

Schnitzler's syndrome is a rather rare disease which may appear in a rheumatologist's office because patients often report rheumatic symptoms with joint, bone and muscle pain. However, it is characterized by chronic urticaria, recurrent fever, liver and spleen enlargement, osteosclerosis, and lymphadenopathy, in conjunction with a serum IgM M component. A patient who had been treated with relat...