Objectives Estrogens and their receptors are postulated to be important factors in development of idiopathic scoliosis. Transcription functions of estrogen receptors are influenced by coregulators such as proline, glutamic acid, and leucine rich protein 1 (PELP1). Deep paravertebral muscles are potential elements participating in idiopathic scoliosis development. The aim of the present study wa...

LBX1 plays a cardinal role in neuronal and muscular development in animal models. Its function in humans is unknown; it has been reported as a candidate gene for idiopathic scoliosis. Our goal is to document the first clinical case of a microduplication at 10q24.31 (chr10:102927883-103053612, hg19), affecting exclusively LBX1. The patient, a 12-year-old girl, showed attention problems, dyspraxi...

Background: Scoliosis is considered as one of the commonest spinal deformity to affect the pulmonary functions because of its ability to alter the respiratory mechanics. Its advancement with age proves fatal because of complications such as respiratory failure. Even though idiopathic scoliosis is also prevalent in India, the data regarding pulmonary function status of these individuals are scan...

BACKGROUND Previous studies have demonstrated that pelvic incidence and sacral slope are significantly greater in idiopathic scoliosis patients compared with normal adolescents. However, whether these sagittal parameters are related to the progression of scoliosis remain unknown. The present was designed to determine the differences in the sagittal profiles among thoracic idiopathic scoliosis p...

Background Adolescent idiopathic scoliosis (AIS) can affect spine mobility and gait mechanisms. In some of the related science research it is showed that the kinematic differences in the spine, pelvis and lower limb may contribute to the causation and progression of idiopathic scoliosis. Various treatment methods have being used for scoliosis, however using brace is a commonly used method in th...

Idiopathic scoliosis is a three-dimensional deformity of the growing spine, affecting 2%-3% of adolescents. Although benign in the majority of patients, the natural course of the disease may result in significant disturbance of body morphology, reduced thoracic volume, impaired respiration, increased rates of back pain, and serious esthetic concerns. Risk of deterioration is highest during the ...

STUDY DESIGN Retrospective analysis of outcome in terms of prevalence of surgery for adolescent idiopathic scoliosis in patients receiving conservative management. OBJECTIVES To determine whether a centre with an active policy of conservative management has fewer patients who eventually undergo surgery for adolescent idiopathic scoliosis than a centre where the practice is non-intervention. ...

To evaluates the effectiveness of schroth exercise with a brace to accelerate changes in cobb angle cases idiopathic scoliosis. This study is literature review narrative method. The research was conducted by tracing and analyzing articles relevant topics raised. data used this secondary data. Sources obtained form or journals topic using Pubmed, Proquest, Google Scholar databases keywords "idio...

Background A large number of studies about adolescents with idiopathic scoliosis focus on health-related quality of life (HRQOL). However, only a few articles aim at evaluating the personality of these patients. Therefore, the purpose of the present research is to assess the personality traits of adolescents with idiopathic scoliosis and their relationship with HRQOL.Our hypothesis is that adol...

Adolescent idiopathic scoliosis (AIS) is a common disease. It is a multi-factorial (polygenic) disease controlled by genetic and environmental factors. Studies searching for genetic factors of AIS using linkage and association analyses have been conducted and several susceptibility genes have been reported. This paper reviews the recent progress in the genome-wide association study of AIS in Ja...