نتایج جستجو برای: ifnβ
تعداد نتایج: 404 فیلتر نتایج به سال:
Molecular characterization, expression of chicken TBK1 gene and its effect on IRF3 signaling pathway
TRAF family member-associated NF-κB activator (TANK)-binding kinase1 (TBK1) is a serine-threonine kinase at the crossroads of multiple interferon (IFN)-inducing signaling pathways in innate immunity. The importance of TBK1 in antiviral immunity is well established in mammal models, but in chicken, the molecular characterization and potential function of TBK1 remain unclear. In the present study...
The physiological function of the immune system and the response to therapeutic immunomodulators may be sensitive to combinatorial cytokine micro-environments that shape the responses of specific immune cells. Previous work shows that paracrine cytokines released by virus-infected human dendritic cells (DC) can dictate the maturation state of naïve DCs. To understand the effects of paracrine si...
Multiple sclerosis (MS) is an autoimmune disease that is characterized by central nervous system inflammation, demyelination, and axon loss. The clinical hallmarks of MS include a pattern of alternating relapses and remissions, and progression of permanent neurologic disability. Several subtypes of MS have been described on the basis of the initial clinical presentation and long-term course of ...
OBJECTIVE The 12-month (M), phase 3, double-blind, randomised TRANSFORMS study demonstrated significant benefits of fingolimod 0.5 or 1.25 mg over interferon β-1a (IFNβ-1a) in patients with relapsing-remitting multiple sclerosis. We report the results of long-term (up to 4.5 years) extension of TRANSFORMS. METHODS Patients randomised to fingolimod (0.5/1.25 mg) in the core phase continued the...
Abstract While systemic lupus erythematosus (SLE) disproportionally affects women versus men, elevation in 17β -estradiol (E2) alone is not sufficient to promote the development of autoantibody producing B cells. The objective present study determine if B-cell intrinsic mechanisms contribute increased TLR7 response E2 stimulation. We identified that there were elevated circulating levels young ...
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