Alzheimer's disease (AD) and frontotemporal dementia (FTD) are two major causes of dementia. These diseases both progressive neurodegenerative whereas no curative treatment has not yet been established. Regenerative approaches have extensively researched for AD FTD, but they still in early phase pre-clinical trials. We show here, the first time, that cytokines such as hepatocyte growth factor (...

The growth hormone (GH)–insulin-like factor (IGF) axis is one of the main drivers mammalian and development. Pituitary secretion GH pulsatile under positive negative hypothalamic control, as well stimulation from gastric-secreted acyl-ghrelin. acts both directly via GH-receptor (GHR) indirectly IGF1 production to induce anabolic metabolic responses at multiple target tissues. In this review, we...

Molecular dynamics computer simulations were used to study the atomistic structure of intergranular films (IGFs) between two basal oriented Si3N4 crystals or between combined basal and prism oriented crystals. Ordering of the ions into the IGF induced by the crystal surfaces was observed using density profiles of the ions, although that ordering is effected by the roughness of the crystal surfa...

In order for the Internet Governance ecosystem to work effectively, it requires a variety of expertise and advice from different sectors backgrounds. Drawing on public Forum (IGF) participation lists 2006 2019, this paper analyses how individual participants chose identify themselves in given frameworks applied across IGFs, they ‘travel’ through over successive fora. Identifying 18,968 unique I...