approximately all sequenced archaeal and half of eubacterial genomes have some sort of adaptive immune system, which enables them to target and cleave invading foreign genetic elements by an rnai-like pathway. crispr–cas (clustered regularly interspaced short palindromic repeats–crispr-associated proteins) systems consist of the crispr loci with multiple copies of a short repeat sequence separa...

Let L be an unbounded linear operator in a real Hilbert space H, a generator of a C0 semigroup, and let g : H → H be a C2 loc nonlinear map. The DSM (dynamical systems method) for solving equation F (v) := Lv+ g(v) = 0 consists of solving the Cauchy problem u̇ = Φ(t, u), u(0) = u0, where Φ is a suitable operator, and proving that i) ∃u(t) ∀t > 0, ii) ∃u(∞), and iii) F (u(∞)) = 0. Conditions on L...

For a code CcX* the following four conditions are considered: (i) for ail words u, v, in X* and for every word w in C*, wu, uv, vu in C* imply u, v in C*. (ii) every onesided infinité product of words of C is unambiguous. (Ui) C has flnite decoding delay. (iv) C has bounded decoding delay. lt is shown that in gênerai (iv) —> (Ui) —• (ii) -* (ï), and the reverse implications are not true; wherea...

Actin is a key regulator of RNA polymerase (pol) II transcription. In complex with specific hnRNPs, it has been proposed that actin functions to recruit pol II coactivators during the elongation of nascent transcripts. Here, we show by affinity chromatography, protein-protein interaction assays, and biochemical fractionation of nuclear extracts that the histone acetyltransferase (HAT) PCAF asso...

We examined the mechanism of action of lysophosphatidylcholine (lyso-PC), which is suggested to be involved in the pathogenesis of atherosclerosis and inflamatory disorders, and its interaction with well-known vasoactive compounds such as hydrogen peroxide (H2O2), thromboxane A2 (TX-A2), serotonin (5-HT), angiotensin II (Ang-II), endothelin-1 (ET-1), or urotensin II (U-II) on VSMC proliferation...

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Betriebliche Informationssysteme zum Produktlebenszyklusmanagement (PLM) dienen in den Unternehmen der Integration von technischer und betriebswirtschaftlicher Informationsverarbeitung. Ihnen kommt eine besondere Bedeutung für die produktbezogene Kostenschätzung im Angebotsengineering und tendenziell für das Lebenszykluskostenmanagement zu. Im vorliegenden Beitrag wird diese zentrale Rolle von ...