نتایج جستجو برای: il1b
تعداد نتایج: 724 فیلتر نتایج به سال:
OBJECTIVE Several research groups have examined osteoarthritis (OA) association with Interleukin-1 (IL-1) region markers and haplotypes. The results have been suggestive for hand OA, negative for knee OA, and conflicting for hip OA. DESIGN Our aim was to address conflicts employing meta-analytical methods on data from 1238 European-descent cases with various OA phenotypes and 1269 European-de...
OBJECTIVE Neuroinflammation contributes to the pathogenesis of sporadic Alzheimer's disease (AD). Variations in genes relevant to inflammation may be candidate genes for AD risk. Whole-genome association studies have identified relevant new and known genes. Their combined effects do not explain 100% of the risk, genetic interactions may contribute. We investigated whether genes involved in infl...
Background: Ultraviolet B irradiation (UVB) contributes to skin inflammation. As UVB mostly affects the epidermis, crosstalk between epidermis and dermis in response needs investigation. Extracellular vesicles (EVs), lipid bilayer membrane secreted by cells, can carry lipids, proteins nucleic acids mediate signal transduction. Stimulator of interferon genes (STING) inflammasome activation-media...
Introduction PFAPA is a pediatric auto-inflammatory syndrome of unknown etiology, characterized by recurrent fever, aphthosis, pharyngitis and cervical adenitis. Dysregulated monocyte interleukin-1 beta (IL-1b) secretion is thought to play an important role in fever flares. Recently, it was published that Thp1 cells (a monocytic cell line) transduced with the Q705K variant of NLRP3 increased IL...
Introduction NOMID/CINCA is the most severe phenotype of cryopyrin-associated periodic syndrome (CAPS), characterized by persistence of inflammation-mediated symptoms and overproduction of interleukin (IL)-1b, associated with significant morbidity, if untreated. In CAPS-patients early initiation of anti-IL1b-treatment appears to prevent severe disease sequelae. However, canakinumab as a 1-line ...
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