IMGT, the international ImMunoGeneTics database (http://imgt.cines.fr), is a high quality integrated information system specializing in Immunoglobulins (IG), T cell Receptors (TR) and Major Histocompatibility Complex (MHC) of human and other vertebrates, created in 1989, by LIGM, at the Université Montpellier II, CNRS, Montpellier, France. IMGT provides a common access to standardized data, whi...

Title Copy number and sequence variation of leucine-rich repeat modules suggests distinct functional constraints operating on variable lymphocyte receptors expressed by agnathan T cell-like and B cell-like lymphocytes Author(s) Sutoh, Yoichi; Kasahara, Masanori Citation Immunogenetics, 66(6): 403-409 Issue Date 2014-06 Doc URL http://hdl.handle.net/2115/59437 Right The original publication is a...

BACKGROUND Bone marrow transplantation has been used in the treatment of various diseases, especially hematologic diseases. The success of this treatment, among other factors, requires human leukocyte antigens (HLA) compatibility between patient and donor. Knowing the human leukocyte antigens allele group and haplotype frequencies as well as the linkage disequilibrium between alleles of differe...

Division of Immunogenetics, Department of Pediatrics, University of Pittsburgh School of Medicine, Rangos Research Center, Children’s Hospital of Pittsburgh, Pittsburgh, PA, 15201 USA Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA USA Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada Department of Medicine, Nationa...

The International Society of Blood Transfusion Working Party on red cell immunogenetics and blood group terminology convened during the International congress in Cancun, July 2012. This report details the newly identified antigens in existing blood group systems and presents three new blood group systems.

1Epidemiology & Genetics Unit, Department of Health Sciences, University of York, York, United Kingdom; 2Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley; 3Department of Biology, University of York, York, United Kingdom; and 4Cancer Immunogenetics Group, School of Cancer and Imaging Sciences, University of Manchester, Manchester, United Kingdom

Allergic bronchopulmonary aspergillosis (ABPA) is a Th2 hypersensitivity lung disease in response to Aspergillus fumigatus that affects asthmatic and cystic fibrosis (CF) patients. Sensitization to A. fumigatus is common in both atopic asthmatic and CF patients, yet only 1%-2% of asthmatic and 7%-9% of CF patients develop ABPA. ABPA is characterized by wheezing and pulmonary infiltrates which m...

Tables 1 and 2 highlight the enormous advances that have been made in the definition of the molecular defects underlying primary immunodeficiencies in the past decade. The identification of SAP as the gene defective in XLP now completes the molecular bases of all the recognised X linked syndromes. Of the autosomally inherited syndromes, only the genes for DiGeorge syndrome, hyper-IgE, and perha...