Most haemolytic disease is mediated by immunoglobulin G (IgG) antibodies and leads to red blood cell destruction outside of the circulatory system. However, rare syndromes, such as paroxysmal cold haemoglobinuria, show IgG antibodies causing intravascular destruction. Haemolysis may also occur because of immunoglobulin M antibodies. Historically, these antibodies have been termed 'cold agglutin...

I describe a rapid, sensitive immunoturbidimetric assay for measuring urinary albumin and immunoglobulin G with use of an automated spectrophotometer. Diluted urine samples and polyethylene glycol in phosphate-buffered saline are pipetted into the cuvettes of the spectrophotometer. The initial absorbances of the samples are measured at 340 nm; antiserum to albumin or to immunoglobulin G is adde...

CASE REPORT The following case shows corneal crystal formation in a patient in whom thee systemic work-up led to the diagnosis of a monoclonal gammopathy with increased monoclonal immunoglobulin G (IgG). We present the corneal signs and subsequent haematological investigations undertaken to establish this important association. DISCUSSION Systemic work-up of a patient with corneal deposits sh...

Using the mouse passive transfer model, the effects of purified human myasthenic immunoglobulin G and of the monovalent Fab fragment on neuromuscular junctions were investigated. Treatment with IgG markedly reduced amplitudes of miniature endplate potentials. When Fab fragments were transferred alone or with subsequent addition of IgG no neuromuscular transmission block was induced. Myasthentic...

The purified Immunoglobulin G (IgG) is effectively used in passive immunization. There are various methods to isolate the IgG from serum, with its own advantages and disadvantages. In the current study, a comparative efficacy of the affinity chromatography using Protein A—Sepharose and ion exchange chromatography using DEAE Sephadex A50 was done with regard to yield and purity of IgG. Both meth...

We provide a novel and versatile signaling transduction strategy in the fluoroimmunoassay through regulating the interaction between graphene (Gr) and graphene quantum dots (GQDs), and demonstrate its feasibility in sensitive detection of human immunoglobulin G (IgG).

In this issue of Blood, Arman et al show that bacteria use immunoglobulin G (IgG) from plasma to engage platelet surface receptors FcγRIIA and integrin αIIbβ3 to induce platelet activation, which is further facilitated by platelet factor 4 (PF4).

A point prevalence study of hepatitis E virus (HEV) in Chinese blood donors was conducted, and the prevalences of antibodies against HEV immunoglobulin G (IgG) and IgM among Chinese blood donors were 32.60% and 0.94%, respectively. HEV viremia was 0.07%.

a case of chronic mucocutaneous candidiasis due to candida albicans in a 13 yr-old boy is reported. evaluation of cell mediated immunity revealed cutaneous anergy to ppd and low level of t-lymphocytes b-cell count and immunoglobulin g (igg) were increased and there was a low level of serum iron. the patient was put under treatment with oral administration of ketoconazole and ferrus sulfate, whi...