Introduction: 90% of the tumors in the head and neck are squamous-cell carcinomas (HNSCC), which have overall 5- year survival rate between 50% -60%. CD44 has been shown to be associated with the prognosis.  Materials and Methods: Biopsy specimens of 51 patients with oral tongue SCC were evaluated by Immunohistochemistry (IHC) for the CD44 antibody.  Results: There was no significant correlatio...

background: systemic lupus erythematosus (sle) has various presentations in children. hematologic abnormalities is common in childhood onset of sle, however, isolated thrombocytopenia is relatively rare. thus, we present a child with isolated thrombocytopenia as a rare presentation of sle. case presentation: a 12-year-old boy with chief complaints of loss of appetite, weight loss, decreased pla...

Minimally invasive intraoperative lymphatic mapping and sentinel node biopsy has become the standard approach for staging the regional lymph nodes for early-stage melanoma. The procedure requires close collaboration of surgeon, pathologist, and nuclear medicine physician. The strength of lymphatic mapping and sentinel node biopsy is its accuracy of detecting occult lymph node metastases. Revers...

background : sentinel lymph node biopsy is used as an accurate staging procedure to detect early breast cancer. several studies have documented that sentinel lymph node biopsy can accurately determine the status of axillary nodes. sentinel node biopsy offers the advantage of accurately staging the axilla and eliminating the need for a full axillary dissection for patients who have a negative se...

AIM PankoMab is a novel antibody that recognizes a tumor-specific epitope of Mucin 1 (MUC1). The aim of this study was the evaluation of PankoMab as a potential diagnostic tool and its comparison with two established antibodies against MUC1 in human ductal breast cancer. MATERIALS AND METHODS Breast carcinomas were obtained from 82 patients. MUC1 expression and hormone receptor status were de...

background: the role of diagnostic pathology has become more prominent. this study aimed to compare the accuracy of frozen section compared with permanent section in the morning and afternoon working hours. methods: in this cross-sectional study, 99 patients with stage 1 and 2 breast cancer who underwent sentinel and non-sentinel lymph node biopsy between 2013 and 2015 were included. the result...

Lipid histiocytosis of the gallbladder neck lymph node is rarely reported nowadays. Two obese patients presented with gallbladder lithiasis detected on CT scan. The treatment consisted in coelioscopic cholecystectomy. Microscopy revealed subacute/chronic lithiasic cholecystitis and foci of vacuolated cells in the gallbladder neck lymph node. These cells were positive for CD68, CD31, S100 protei...

castleman disease (cd) is a rare, lymphoproliferative disorder of uncertain etiology. we are reporting on two cases of castleman disease. both patients were female. this disease can be found wherever lymph nodes are present. we have reported two unusual cases of castleman disease. a 29- year old woman was referred for evaluation because of a cervical lymph node, weight loss and night sweats. th...