Atopic dermatitis (AD) is a chronic, inflammatory and pruritic skin disease with a prevalence of 10-20%. Recent studies suggested the effect of selenium on immunoregulation in AD. In this study we report 4 cases of atopic dermatitis according to Hafniin and Rajka criteria. Serum selenium levels were increased and serum total IgE were decreased in all patients. These results show that selenium i...

Branka Horvat, France Stephen C. Jameson, USA Stipan Jonjic, Croatia Bruno Kyewski, Germany Foo Y. Liew, UK Miodrag L. Lukic, Serbia Ofer Mandelboim, Israel Andrew N. McKenzie, UK Lorenzo Moretta, Italy Sergei Nedospasov, Russia Mihai G. Netea, The Netherlands Janko Nikolich-Zugich, USA Annette Oxenius, Switzerland Nada Pejnović, Serbia Bojan Polić, Croatia Alehander Rudensky, USA Hannes Stocki...

1 Department of Advanced Nephrology and Regenerative Medicine, Graduate School of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8655, Japan 2Department of Immunology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minamiku, Sagamihara, Kanagawa 252-0374, Japan 3Division of Nephrology, Department ofMedicine, State University of NewYork at Buffalo, School ofMedicine a...

Beneficial microbes are responsible for the synthesis of nutrients and metabolites that are likely important for the maintenance of mammalian health. Many nutrients and metabolites derived from the gut microbiota by luminal conversion have been implicated in the development, homeostasis and function of innate and adaptive immunity. These factors clearly suggest that intestinal microbiota may in...

Taenia crassiceps is a cestode parasite of rodents (in its larval stage) and canids (in its adult stage) that can also parasitize immunocompromised humans. We have studied the immune response elicited by this helminth and its antigens in mice and human cells, and have discovered that they have a strong capacity to induce chronic Th2-type responses that are primarily characterized by high levels...

Pathogens causing tuberculosis and other chronic infectious diseases of major public health importance commonly have complex mechanisms involved in their persistence in the host despite specific and sometimes strong immune responses. These diseases are also associated with the lack of efficient vaccines, difficult therapeutics and a high mortality rate among susceptible individuals. Here, we wi...

Inflammation is a protective response that occurs in to tissue injury and microbial infections. A significant advancement has been made our understanding of inflammation, which one the most fundamental concepts medicine. Immunoregulation immune-mediated inflammatory diseases depends on Th17/Treg balance. Costimulatory receptors, cytokines, metabolic pathways, intestinal microbiome all affect th...