Transcription and translation use raw materials and energy generated metabolically to create the macromolecular machinery responsible for all cellular functions, including metabolism. A biochemically accurate model of molecular biology and metabolism will facilitate comprehensive and quantitative computations of an organism's molecular constitution as a function of genetic and environmental par...

Background:Â Malaria is an endemic disease that can lead to death. control a threatening cause of resistance antimalarial drugs so renewable therapies are needed overcome this disease. The chemical compounds garlic have potential as agents, but the mechanism still unknown. Aim:Â This research will predict compounds' molecular in (Allium sativum) using in-silico method. Methods:Â In-silico metho...

Evolution should have played important roles in determining folding mechanisms and structures of proteins. In this article we discuss how the folding mechanisms had been affected by the early stage of evolution through which the uniqueness of structure had developed. Although the process of such early-time evolution has remained a mystery, a plausible scenario is that the evolution of proteins ...

in the present paper, a 3d numerical model has been applied to predict the flow hydrodynamics around power intakes within the dez dam reservoir. the dez dam is a 203 m high, double arch concrete dam which is constructed by italians in 1962. since then, sedimentation in reservoirhas continued and since the dam does not have bottom outlet, the reservoir bed level is raising by a rate of about 2.5...

The paper presents a model for simulating the protein folding process in silico. The two-step model (which consists of the early stage-ES and the late stage-LS) is verified using two proteins, one of which is treated (according to experimental observations) as the early stage and the second as an example of the LS step. The early stage is based solely on backbone structural preferences, while t...

it has been suggested that single nucleotide polymorphisms (snps) in genes involved in toll-like receptors (tlrs) pathway may exhibit broad effects on function of this network and might contribute to a range of human diseases. however, the extent to which these variations affect tlr signaling is not well understood. in this study, we adopted a bioinformatics approach to predict the consequences...

The advent of 3D printers has been embraced globally within few years of its emergence. The surge in the acceptability of rapid manufacturing RM technology can be attributed to the depletion and cost of natural resources, waste reduction and sustainability criterion of manufactured parts. This rapidly evolving 3D printing technologies is predicted to grow exponentially especially for the manufa...

Upper Gotvand dam is constructed on the Karun River located in the south west of Iran. In this paper, 2D and 3D models of the dam together with the foundation and abutments were constructed and several seepage analyses were carried out. Then the gypsum veins scattered throughout the foundation ground and also the seepage pattern were included in the models, hence the dissolution law of gypsum, ...

In the present study, the antimicrobial tests of patchouli oil were studied by using molecular docking technology and antimicrobial test in vitro. Five biological macromolecule enzymes, required by the bacteria in the process of biosynthesis were selected as target molecules. Five antibiotics benzylpenicillin, sulfadiazine, trimethoprim, rifampicin and ciprofloxacin, which are generally acknowle...