the aim of this study was to develop an extended-release tablet formulation using a new in situ cross-linking method. the effects of polyvalent cations on theophylline release from tablets made with the polyanionic polymers sodium alginate and sodium carboxymethylcellulose, were investigated. different miliequivalents of the di and tri-valent cation, ca2+ and al3+, were added to tablet formulat...

this paper introduces an innovative partially destructive method, called “twist-off”, for the assessment of in situ concrete strength. in this method a 40mm diameter metal probe is bonded to a concrete surface by means of a high strength epoxy resin adhesive. to measure the concrete compressive strength, a torque is applied using an ordinary torque-meter and the maximum shear stress at failure ...

abstract with increasing population, mine activities for metal proceeding are also increasing, so environment will be influenced by contaminant especially heavy metals. in situ immobilization of heavy metals using inexpensive amendments is considered as a simple and cost-effective approach for reducing heavy metal contamination. in this research we used sequential extraction for assessing reduc...

Objective(s): In this study, a stable bear bile-loaded pH sensitive in-situ eye drop gel was prepared for sustain delivery and enhanced therapeutic application. Materials and Methods: Bear bile-loaded in-situ ocular gels with different Carbopol/Hydroxypropyl methylcellulose (HPMC)  ratios were prepared and their stability was tested in P...

Background: Herpes simplex virus type-1 (HSV-1) establishes a lifelong latent infection in neurons following primary infection. The existence of latent HSV-1 DNA in the trigeminal ganglia of infected BALB/c mice was examined using a direct in situ PCR technique, based on Digoxigenin-11-dUTP detection system with anti-digoxigenin-peroxidase and 3,3'-diaminobenzidine (DAB) substrate. Methods: Eig...