Protein kinase B (PKB/Akt) belongs to the AGC superfamily of related serine/threonine protein kinases. It is a key regulator downstream of various growth factors and hormones and is involved in malignant transformation and chemo-resistance. Full-length PKB protein has not been crystallised, thus studying the molecular mechanisms that are involved in its regulation in relation to its structure h...

Mutations in the ganglioside-induced differentiation associated protein 1 (GDAP1) cause severe peripheral motor and sensory neuropathies called Charcot-Marie-Tooth disease. GDAP1 expression induces fission of mitochondria and peroxisomes by a currently elusive mechanism, while disease causing mutations in GDAP1 impede the protein's role in mitochondrial dynamics. In silico analysis reveals sequ...

HtrA2(Omi) protease controls protein quality in mitochondria and plays a major role in apoptosis. Its HtrA2S306A mutant (with the catalytic serine routinely disabled for an X-ray study to avoid self-degradation) is a homotrimer whose subunits contain the serine protease domain (PD) and the regulatory PDZ domain. In the inactive state, a tight interdomain interface limits penetration of both PDZ...

this study aimed at investigating the variations of blood pressure, heart rate and oxygen consumption and their relationship with body lipid profile in active and inactive students. 10 active students (mean age 21 yr, weight 68.1 kg and height 174.1 cm) and 10 inactive students (mean age 21.5 yr, weight 73.07 kg and height 177 cm) from shahid rajaee teacher training university who volunteered t...

Phosphorylation is a common mechanism for activating proteins within signaling pathways. Yet, the molecular transitions between the inactive and active conformational states are poorly understood. Here we quantitatively characterize the free-energy landscape of activation of a signaling protein, nitrogen regulatory protein C (NtrC), by connecting functional protein dynamics of phosphorylation-d...

In this work we consider the problem of control of mechanical systems subject to unilateral constraints. Impulsive forces arise whenever the constraints become active and these forces give rise to nonsmooth dynamics. The dynamics of the system is de ned by a set of di erential equations with discontinuous righthand side using Hamilton's equations of motion. A nonlinear transformation is applied...