Mutations in Alsin are associated with chronic juvenile amyotrophic lateral sclerosis (ALS2), juvenile primary lateral sclerosis and infantile-onset ascending spastic paralysis. The primary pathology and pathogenic mechanism of the disease remain largely unknown. Here we show that alsin-deficient mice have motor impairment and degenerative pathology in the distal corticospinal tracts without ap...

Many children who are admitted to pediatric hospitals with the chief complaint of apparent life-threatening event (ALTE) are, in fact, well appearing by the time the inpatient medical team evaluates the patient. This presents a diagnostic and therapeutic challenge. We describe a case of a six-month-old full-term female presenting with an ALTE and found to have a double aortic arch, a congenital...

Two 4 week old infants are reported who suffered apparent life threatening events (ALTE) while being cradled in adult arms. The events, which could be reproduced under controlled circumstances, were not associated with any struggling by the infants. Alteration of infant holding practices in both cases resulted in cessation of the events. A case of cardiorespiratory arrest during breast feeding ...

INTRODUCTION The conventional 24-hour pH monitoring is the gold standard for the diagnosis of gastro-esophageal reflux (GER), a possible cause of Apparent Life Threatening Episodes (ALTE). However, multichannel intraluminal impedance (MII) may provide advantages. OBJECTIVES Comparison of the results of MII and pH monitoring in patients undergoing MII-pH monitoring in the 3-year study period b...

Most isolated episodes of apparent life-threatening events (ALTEs) do not lead to the diagnosis of serious conditions, and their prognoses are generally benign. However, recurrent ALTEs are often associated with a risk of future serious adverse events and should be evaluated for appropriate management. Here we present ALTE case in which gastric volvulus associated gastroesophageal reflux diseas...

conclusions in conclusion, the results of our study showed that the major viral pathogens that caused infantile diarrhea in zabol city were rotaviruses followed by adenoviruses and noroviruses. the results of our study can useful for prosperous control of infantile diarrhea. background viruses are one of the major reasons of gastrointestinal disease worldwide, and commonly infect children less ...

how to cite this article:  fallah r, salor f, akhavan karbasi s, motaghipisheh h. randomised clinical efficacy trial of topiramate and nitrazepam in treatment of infantile spasms. iran j child neurol. 2014 winter; 8(1):12-19. objective infantile spasms (is) are among the most catastrophic epileptic syndromes of infancy. the purpose of this study was to compare efficacy and safety of topiramate ...

Sympatheticovagal imbalance causing episodes of severe bradycardia has been suggested as a cause of apparent life threatening events (ALTEs). The autonomic control of the heart rate in 18 infants with ALTEs and 12 controls was evaluated by the head upright tilt test. Five different heart rate response profiles (compared with the baseline) were observed during the tilt: (1) increase followed by ...