To assess the frequency of malignancy-associated 30-bp deletion variants of the latent membrane protein 1 (LMP-1) in benign conditions, a comparative sequence analysis was done using samples from 20 American children with acute infectious mononucleosis and 16 Swiss children with chronic tonsillar hyperplasia. The 30-bp deletion variant (LMP-1-del) was present in 66% of patients (12/20 with infe...

A 35-year-old man was admitted because of significant hepatic dysfunction with mild splenomegaly and intra-abdominal lymphadenopathy of unknown cause. Infectious mononucleosis was suggested by subsequently detected high fever, pharyngotonsillitis and cervical lymphadenopathy, but IgM to Epstein-Barr virus (EBV) and cytomegalovirus (CMV) showed dual positivity. A definite diagnosis of EBV-induce...

The web of causation is closing in on EB virus in its relation to certain conditions. In heterophile positive infectious mononucleosis the web of causation seems established beyond any reasonable doubt (1-3). The evidence derived from prospective serological studies that EBV antibody is regularly absent prior to infectious mononucleosis and regularly appears during illness (4-7) is supported by...

Gallbladder wall thickening (3 mm or greater) is a nonspecific finding with many causes. We describe two cases caused by infectious mononucleosis. Other causes of gallbladder wall thickening are described and the literature is reviewed. We suggest that the finding of gallbladder wall thickening in a patient with infectious mononucleosis implies that the patient is very ill, and its observation ...

By RICHARD M. ANGLE, M.D. , AND HOWARD L. ALT, M.D. T HE OCCURRENCE of thrombocytopenic purpura during the course of infectious mononucleosis is rare. A review of the literature revealed only six detailed reports of a definite association between these two conditions. It is the purpose of this paper to report another case and to present the results of serial blood platelet counts during the cou...

The EBV IgG titres in acute and convalescent specimens from 97 cases of infectious mononucleosis were compared with titres from acute and convalescent sera from 96 students with illnesses resembling infectious mononucleosis but without heterophil antibody, EB IgM or EB IgG seroconversion; and also with titres from 91 healthy students known to have had EB IgG antibody for at least six months. Th...

MONG the features of infectious lymphadenosis (‘ ‘mononucleosis’ ‘) which help to distinguish it from acute lymphatic leukemia is the lack of reduction in both red cells and platelets. Conversely, the association of well-defined anemia and/or thrombocytopenia with a marked degree of lymphocytosis in which abnormal lymphocytes are conspicuous, almost certainly indicates acute leukemia. The prese...

BACKGROUND Splenic rupture or infarction can occur secondary to acute infectious mononucleosis. Patients with abdominal pain and known or suspected infectious mononucleosis mandate evaluation for these complications, which can have significant morbidity or mortality. CASE REPORT An 18-year old man presented to the emergency department (ED) with a 2-day history of left upper quadrant abdominal...

■ Evidence summary The annual incidence of infectious mononucleosis is somewhere between 345 and 671 cases per 100,000 in the US; it is highest in the adolescent age group. Splenic rupture is the leading cause of death in infectious mononucleosis, occurring in 0.1% to 0.2% of all cases. Based on this figure, approximately 100 cases of rupture may occur yearly in the US, only a few of which are ...

Immunoglobulin A (IgA) antibodies to Epstein-Barr virus viral capsid antigen were assayed serially in 19 patients with infectious mononucleosis and in 38 controls. Seventy-four percent of infectious mononucleosis patients demonstrated IgA antibody, whereas this was found in 13% of controls. This antibody appeared early in infectious mononucleosis and was virtually gone 10 weeks after onset. Com...