Connections between inflammation and diseases are suggested important in understanding the genetic mechanisms of diseases. However, studies on the functional cross-links between inflammation and disease genes are still in their early stages. We integrated the protein-protein interaction (PPI), inflammation genes, and gene-disease associations to construct a disease-inflammation network (DIN). W...

BACKGROUND Many studies try to identify cancer diagnostic biomarkers by comparing peripheral whole blood (PWB) of cancer samples and healthy controls, explicitly or implicitly assuming that such biomarkers are potential candidate biomarkers for distinguishing cancer from nonmalignant inflammation-associated diseases. METHODS Multiple PWB gene expression profiles for lung cancer/inflammation-a...

The crucial roles of oxidative stress and inflammation in the development of hepatic diseases have been unraveled and emphasized for decades. From steatosis to fibrosis, cirrhosis and liver cancer, hepatic oxidative stress, and inflammation are sustained and participated in this pathological progressive process. Notably, increasing evidences showed that oxidative stress and inflammation are tig...

Metabolic diseases, such as obesity and type 2 diabetes, are world-wide health problems. The prevalence of metabolic diseases is associated with dynamic changes in dietary macronutrient intake during the past decades. Based on national statistics and from a public health viewpoint, traditional approaches, such as diet and physical activity, have been unsuccessful in decreasing the prevalence of...

Inflammation plays a significant role in many disease processes. Development in molecular imaging in recent years provides new insight into the diagnosis and treatment evaluation of various inflammatory diseases and diseases involving inflammatory process. Positron emission tomography using (18)F-FDG has been successfully applied in clinical oncology and neurology and in the inflammation realm....

Reactive oxygen and nitrogen species have been implicated in diverse pathophysiological conditions, including inflammation, neurodegenerative diseases and cancer. Accumulating evidence indicates that oxidative damage to biomolecules including lipids, proteins and DNA, contributes to these diseases. Previous studies suggest roles of lipid peroxidation and oxysterols in the development of neurode...

Epidermis, composed primarily of the keratinocytes, is subjected to ultraviolet radiation (UVR)-induced oxidative and genotoxic stresses. That keratinocytes are initial source pro-inflammatory mediators in skin after UVR exposure has been well established. Ultraviolet B (UVB) a strong initiator cutaneous inflammation, contributes etiology exacerbation several diseases, such as lupus erythematos...

Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are relatively common, severe autoimmune diseases. These two diseases represent examples of a larger number of autoimmune diseases such as multiple sclerosis, Crohn’s Disease, ulcerative colitis, juvenile diabetes, and psoriasis, among many others that collectively affect millions of Americans. Basic and clinical studies have show...

objective: autoimmune diseases precede a complex dysregulation of the immune system. t helper17 (th17) and interleukin (il)-17 have central roles in initiation of inflammation and subsequent autoimmune diseases. il-27 significantly controls autoimmune diseases by th17 and il-17 suppression. in the present study we have created genetic engineered mesenchymal stem cells (mscs) that mediate with l...