Cutaneous lupus erythematosus (CLE) is a manifestation of systemic (SLE) that can cause significant patient distress due to scarring. Mechanisms scarring remain poorly understood and interventions for prevention treatment are lacking. Fibroblasts (FBs) involved in inflammation scarring, yet the role inflammatory mediators on FB function SLE unclear. In this study, we examined phenotype FBs isol...

Dasatinib (DASA) is a novel tyrosine kinase inhibitor, approved for leukemia treatment. However, the long-term use of DASA induces several complications, especially liver damage. On other hand, Naringenin (NGN) potent antioxidant and anti-inflammatory agent which known to exert protective effects in disease animal models. Yet, effect NGN on DASA-induced hepatotoxicity has not been examined. Thi...

Abstract Macrophages play a variety of roles in immunity including both pro- and anti-inflammatory functions, which can be controlled by toll-like receptor (TLR) stimulation. Previously, we generated computational model interconnected TLR signaling cascades validated the using experimental data from THP-1 monocyte cell line. This project aimed to adapt provide insights into activation bone marr...

Acinetobacter baumannii is increasingly becoming a major nosocomial pathogen. This opportunistic pathogen secretes outer membrane vesicles (OMVs) that interact with host cells. The aim of this study was to investigate the ability of A. baumannii OMVs to elicit a pro-inflammatory response in vitro and the immunopathology in response to A. baumannii OMVs in vivo. OMVs derived from A. baumannii AT...

CONTEXT AND OBJECTIVE: Diet is an important modifiable factor involved in obesity-induced inflammation. We reviewed clinical trials that assessed the effect of consumption of different fatty acids on the expression of inflammation-related genes, such as cytokines, adipokines, chemokines and transcription factors. DESIGN AND SETTING: Narrative review study conducted at a research center. MET...

Background: Nutrition is a significant risk factor for the incidence of periodontal disease. Nutrients acting on human genome, either directly or indirectly, can change expression and structure genes. One micronutrients associated with periodontitis vitamin D. Vitamin D has an important role in bone calcium metabolism regulates serum phosphate concentrations at normal limits. Purpose: To discus...

Objective: To examine the effects of Trichosanthes kirilowii Maximowicz extract (TE) and Maxi mowicz Cheonghyeol Plus Phellinus linteus plus (TCP) on anti-inflammatory factor expression in human umbilical vein endothelial cells (HUVECs).Methods: HUVECs were activated with TNF-α then treated TE TCP. The levels measured for intracellular genes (KLF2, eNOS, MCP-1, ICAM-1, VCAM-1), proteins VCAM-1,...

BACKGROUND Overweight and obesity are becoming more widespread with alarming projections for the coming years. Obesity may increase susceptibility to the adverse effects of PM exposure, exacerbating the effects on cardiovascular diseases and altering the biomarkers of vascular inflammation. The associated biological mechanisms have not been fully understood yet; the common denominator in the pa...

Abeliophyllum distichum has been demonstrated to possess anticancer, anti-inflammatory, anti-osteoporotic, and anti-obesity effects. However, there is a limitation using this shrub as beneficial material, because had listed endangered. Thus, we established an adventitious root culture of A. (AdAR) overcome limitation. Solvent-solvent partition fractions from methanol extract methyl jasmonate (M...

Background Endometriosis is a common gynecological disease, can cause severe pelvic pain. Studies demonstrated the presence of sensory nerve fibers in endometrium of endometriosis patient. Nevertheless, no information is available on mechanisms of sensory nerve formation in eutopic or ectopic lesions. Since HOX genes have important roles in both reproductive tract and nerve growth, we decided t...