Background and Aims: Since 1998, Iranian poultry industry has been affected by avian influenza (AI) virus, subtype H9N2. The association of high mortality and case report of H5N1 and H9N2 influenza virus in wild birds in recent years raised the suspicion of a possible new genetic modified AI virus. Methods: Partial nucleotide sequences and deduced amino acid of hemagglutinin (HA) genes of 4 H9...

1. Hause BM, Ducatez M, Collin EA, Ran Z, Liu R, Sheng Z, et al. Isolation of a novel swine influenza virus from Oklahoma in 2011 which is distantly related to human influenza C viruses. PLoS Pathog. 2013;9:e1003176. http://dx.doi.org/10.1371/ journal.ppat.1003176 2. Ducatez MF, Pelletier C, Meyer G. Influenza D virus in cattle, France, 2011–2014. Emerg Infect Dis. 2015;21:368–71. 3. Hause BM, ...

background and aims: each year, the influenza virus causes moderate to severe infections with a high prevalence throughout the world. accordingly, an influenza vaccine that ensures protection with only a single dose would be a much more cost effective approach to influenza prophylaxis. generation of influenza non-replicating virus-like particles (vlp) in baculoviral expression system is an attr...

We have recently reported the isolation of a novel virus, provisionally designated C/swine/Oklahoma/1334/2011 (C/OK), with 50% overall homology to human influenza C viruses (ICV), from a pig in Oklahoma. Deep RNA sequencing of C/OK virus found a matrix 1 (M1) protein expression strategy that differed from that of ICV. The novelty of C/OK virus prompted us to investigate whether C/OK virus could...

background and aims: virus-like particles (vlps) have been suggested to be a promising recombinant vaccine approach. several studies have reported that the influenza vlps produced in insect cells is an effective vaccine candidate. due to crucial role of matrix m1 protein in assembly and budding of influenza particles, in all vlps structures, m1 protein have been considered as a main component. ...

background in 2009, a pandemic associated with a new type of influenza a virus (h1n1) affected many countries worldwide. after five years of silence, in 2015 we encountered another outbreak of h1n1 influenza a. objectives the present study aimed to study the epidemiological and clinical features of this disease in the cold and dry climate of qazvin province, iran in the last epidemic, during 20...

background emergence of a novel swine-origin influenza a (h1n1) pandemic since 2009 attracted the attention of scientists to characterize epidemiological features and clinical manifestations of this disease in comparison to seasonal flu in different parts of the world. objectives the goal of this investigation was to compare these features in confirmed cases of swine-origin influenza a (h1n1) a...

conclusions: prevalence rate of h1n1 infection in the study region was higher compared to other part of iran; but, close to the expected rate. the h1n1-associated mortality rate was lower than the reported rates in iran and other parts of the world. background: khuzestan and other parts of iran were involved with influenza a (h1n1) pandemic in 2009. objectives: the aim of this study was to desc...