BACKGROUND Onychomycosis, a fungal nail infection, can impact quality of life. OBJECTIVE We sought to evaluate the efficacy and safety of tavaborole topical solution, 5% for treatment of toenail onychomycosis. METHODS In 2 phase-III trials, adults with distal subungual onychomycosis affecting 20% to 60% of a target great toenail were randomized 2:1 to tavaborole or vehicle once daily for 48...

Chromium intake may increase insulin sensitivity, glucose tolerance, and the ratio of high density lipoprotein cholesterol to low density lipoprotein cholesterol. However, the epidemiologic evidence on the association between chromium and cardiovascular disease is very limited. To determine whether low toenail chromium concentrations were associated with risk of nonfatal myocardial infarction, ...

OBJECTIVE To compare the efficacy and safety of continuous terbinafine with intermittent itraconazole in the treatment of toenail onychomycosis. DESIGN Prospective, randomised, double blind, double dummy, multicentre, parallel group study lasting 72 weeks. SETTING 35 centres in six European countries. SUBJECTS 496 patients aged 18 to 75 years with a clinical and mycological diagnosis of d...

BACKGROUND Fungal infection of the nail affects millions of people worldwide and has an estimated prevalence of more than 10% of the general population. OBJECTIVES To determinate the prevalence of fungal infection in toenails, in order to decide the treatment policy for onychomycosis. METHODS We evaluated 331 patients with suspected clinical toenail onychomycosis affecting at least two toen...

BACKGROUND Little is known about the carcinogenic potential of arsenic in areas with low to moderate concentrations of arsenic (< 100 microg/L) in drinking water. OBJECTIVES We examined associations between arsenic and lung cancer. METHODS A population-based case-control study of primary incident lung cancer was conducted in 10 counties in two U.S. states, New Hampshire and Vermont. The stu...

We assessed the reproducibility over a 6-year period of 16 trace elements measured in toenails by comparing levels in paired specimens collected in 1982-1983 and 1988 from 127 women in the United States. The Spearman correlation coefficients for the reproducibility of toenail levels of selenium and arsenic (both known to reflect intake of these elements) were 0.48 and 0.54. Correlations for oth...

Results of a randomized controlled trial have suggested a protective effect of selenium against prostate cancer. Few other prospective studies have been conducted to confirm or refute this. The association between prostate cancer and baseline toenail selenium level was evaluated in the Netherlands Cohort Study, conducted among 58,279 men, aged 55-69 years at entry. In September 1986, the cohort...

INTRODUCTION Fungal infections are reported to cause 23% of foot diseases and 50% of nail conditions in people seen by dermatologists, but are less common in the general population, affecting 3% to 12% of people. METHODS AND OUTCOMES We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of oral treatments for fungal toenail infections in a...