The neurodevelopmental hypothesis of schizophrenia suggests that subtle anomalous brain development occurs in utero which reveals itself symptomatically, years later, as the heterogeneous symptoms of schizophrenia. This paper briefly reviews data on the presence of minor physical anomalies in those affected by schizophrenia and also summarizes a few results from structural brain imaging studies...

hyperekplexia is a rare non-epileptic disorder characterized by an exaggerated and persistent startle reaction to the unexpected tactile and acoustic stimuli. the disorder is occasionally associated with generalized muscular rigidity and has the clinical hallmark of positive nose tapping test. the disease is inherited in an autosomal dominant fashion.  recessively inherited and sporadic forms o...

chronic granulomatous disease is an inherited defect in intracellular killing of ingested microorganisms characterized by recurrent life threatening bacterial and fungal infections including invasive aspergillosis in early childhood. we report  a  disseminated aspergillosis as  the  representative  of  adult  onset  chronic granulomatous disease without previous infection, with dramatic respons...

OBJECTIVE Infantile Krabbe disease, a rare neurodegenerative disorder that leads to rapid demyelination, dysmyelination, and death in the first 2 years of life, is responsive to treatment with umbilical cord blood transplantation provided that the patient is treated in the first weeks of life. At present, family history is the only way to identify patients that are asymptomatic with most patien...