Nanophotonics, Nanoelectronics and Nanosensor (N3) is part of International Photonics and OptoElectronics Meetings (POEM), launched by Wuhan National Laboratory for Optoelectronics (WNLO). POEM is a large-scale multi-disciplinary international conference in the field of photonics and optoelectronics. It aims to focus on the key techniques of scientific frontier and industry in the field of opto...

Achalasia is a primary motility disorder with an annual incidence of 0.11 cases/ 100000 children [1]. In the field of natural orifice transluminal endoscopic surgery (NOTES), the peroral endoscopic myotomy (POEM) [2–3] is the only treatment to be performed routinely in humans. We report the case of a 3-year old female patient with Down syndrome who presented with severe growth retardation and w...

A clinically relevant model of spontaneous breast cancer metastasis to multiple sites, including bone, was characterized and used to identify genes involved in metastatic progression. The metastatic potential of several genetically related tumor lines was assayed using a novel real-time quantitative RT-PCR assay of tumor burden. Based on this assay, the tumor lines were categorized as nonmetast...

Esophageal achalasia is considered as a risk factor of esophageal cancer. The etiologies of esophageal achalasia remain unknown. Peroral endoscopic myotomy (POEM) has recently been established as a minimally invasive method with high curability. The aims of the present study were to identify the microRNAs (miRs) specific to esophageal achalasia, to determine their potential target genes and to ...

Background and study aims Peroral endoscopic myotomy (POEM) is an excellent endoscopic treatment for achalasia. Clinical and manometric parameters are used for evaluation and follow-up. However, clinical success does not guarantee high quality of life (QoL) scores, generating doubts about their direct relationship. We aimed to evaluate QoL scores before and after POEM at medium and long term, t...

We develop a learning principle and an efficient algorithm for batch learning from logged bandit feedback. This learning setting is ubiquitous in online systems (e.g., ad placement, web search, recommendation), where an algorithm makes a prediction (e.g., ad ranking) for a given input (e.g., query) and observes bandit feedback (e.g., user clicks on presented ads). We first address the counterfa...

Background: Based on Chicago Classification version 3.0, the disorders of esophagogastric junction outflow obstruction (EGJOO) include achalasia (types I, II and III) and EGJOO. Although no curative treatments are currently available for the treatment of the disorders of EGJOO, medical treatments, endoscopic pneumatic dilation (PD), laparoscopic Heller myotomy (LHM), and per-oral endoscopic myo...

Dear Editor, Peroral endoscopic myotomy (POEM) is a treatment for achalasia which can potentially obviate the need for intraabdominal surgery, whilst at the same time, deliver the same effective treatment as the current standard of care – surgical myotomy. Although POEM has shown encouraging 1-year success rates of more than 90%,1-3 it remains a technically demanding procedure. In the absence o...

William Empson’s poem ‘Letter I’ (1928–35) appears to anticipate the black hole, using the idea of a dying star from which no light escapes as a metaphor for unrequited passion. Closer inspection of the Cambridge undergraduate context in which the poem was written, along with the other source materials incorporated besides Arthur Eddington in the poem, reveals the motivation behind Empson’s pla...