The study was aimed to investigate the molecular mechanisms underlying triggering of apoptosis by quercetin using in silico analysis. The mechanism of binding of quercetin with NF-kB and other apoptotic proteins like BCL2 and BCLXL was analyzed in silico using Schrodinger suite 2009.Quercetin was found to exhibit high-affinity binding resulting from greater intermolecular forces between the lig...

Leishmaniasis is a parasitic disease caused by the protozoan Leishmania, which is active in two broad forms namely, Visceral Leishmaniasis (VL or Kala Azar) and Cutaneous Leishmaniasis (CL). The disease is most prevalent in the tropical regions and poses a threat to over 70 countries across the globe. About 200 million people are estimated to be at risk of developing VL in the Indian subcontine...

Objective: Insulin-like growth factor 1 receptor (IGF-1R) is over-expressed in a number of cancer cell lines and has been implicated to play a role in oncogenesis and suppression of apoptosis. Thus, the inhibition of IGF-1R activity leads to tumor regression and renders IGF-1R a plausible target for the development of anti-cancer drugs. Dietary agents are known to interfere with IGF signaling a...

Identification of a therapeutic micro RNA (miRNA) with multiple gene targets is a major challenge in the era of post genomics and the ability to apply an accurate insilico approach leads to the initiation of discovering novel miRNAs. In order to identify a micro RNA (miRNA) based target interaction among the genes which are associated with pharmacology; we have taken a list of Psoriasis related...

Invulnerability of Mycobacterium tuberculosis to various drugs and its persistency has stood as a hurdle in the race against eradication of the pathogenecity of the bacteria. Identification of novel antituberculosis compounds is highly demanding as the available drugs are resistant. The ability of the bacteria to surpass the body's defenses and adapt itself to survive for disease reactivation i...

Dengue has reemerged significantly from the past two decades for the public health problems. Clinicians require a diagnostic test with high sensitivity, which is applicable during early symptomatic phase. PCR is a specific and sensitive molecular technique to detect the gene for monitoring possible Dengue outbreaks and circulating viral serotypes. Bioinformatics tools were used to design and ve...