The acknowledgement of risks for traumatic brain injury in American football players has prompted studies for sideline concussion diagnosis and testing for neurological deficits. While concussions are recognized etiological factors for a spectrum of neurological sequelae, the consequences of sub-concussive events are unclear. We tested the hypothesis that blood-brain barrier disruption (BBBD) a...

BACKGROUND Chronic hepatitis C infection is frequently associated with a mixed cryoglobulinaemia and circulating auto-antibodies, especially anti-smooth muscle cells (SMA) and anti-liver/kidney/microsome type 1 (LKM-1) anti-tissue antibodies. Treatments with TNF antagonists favour the emergence of auto-antibodies, and particularly anti-dsDNA antibodies. OBJECTIVE To determine the impact of TN...

The importance of islet cell antibodies (ICA) as a predictor of insulin dependent diabetes mellitus (IDDM) has been emphasized by several investigators since 1974. The ICA was also detected in patients with various immune-mediated diseases such as auto-immune thyroiditis. Schistosomiasis is a wide-spread helminthic disease which affects more than 200 million patients all over the world. Immunol...

Since the discovery that auto-antibodies to thyroglobulin were present in cases of Hashimoto's disease (Doniach and Roitt, 1957), a search for auto-antibodies has been made in various diseases of otherwise obscure origin. Ophthalmology has already provided the first confirmed example of an auto-antibody causing disease in the condition endophthalmitis phako-anaphylactica; a similar explanation ...

Type 1 diabetes (T1D) is a chronic disease caused by destruction of the insulin producing beta-cells in the pancreas. The incidence of T1D has increased rapidly, especially in the Western world and among young children. The pathogenesis of T1D is not fully understood, but the beta-cells are believed to be destroyed by an autoimmune process initiated years before the onset of T1D. During this pr...

OBJECTIVE To determine the predictive value of the presence of maternal islet beta-cell autoantibodies with respect to neonatal outcomes. METHODS A total of 311 pregnant women with abnormal 75 g oral glucose tolerance test (OGTT) results were enrolled in this study. Maternal glutamic acid decarboxylase autoantibodies (GADA), islet cell autoantibodies (ICA) and insulin autoantibodies (IAA) wer...

In the present study, we aimed to estimate the concentrations of cytokines (interleukin 6, IL-6, tumor necrosis factor-α, TNF-α) and auto-antibodies (rheumatoid factor IgM isotype, IgM-RF, antinuclear auto-antibodies, ANA, anti-cyclic citrullinated peptide antibodies IgG isotype, IgG anti-CCP3.1, anti-cardiolipin IgG isotype, IgG anti-aCL) in serum of patients with eRA (early rheumatoid arthrit...

autoimmune hepatitis is (aih) is a chronic hepatitis that occurs in children and adults of all ages. it is characterized by immunologic and autoimmune features, including circulating auto antibodies and high serum globulin concentrations. it was first described in the 1950s by term of chronic active hepatitis. it has 2 types with different auto antibodies. diagnosis is based upon serologic and ...