Amyloidosis consists of approximately 30 protein-folding disorders in which a specific soluble precursor protein aggregates to form the insoluble fibrils amyloid. Insulin is hypothesized localized cutaneous insulin-derived (AIns) amyloidosis. Amyloid deposition at insulin injection sites can interfere with absorption, leading poor glucose control. Despite increasing prevalence diabetes mellitus...

Presented at the International Society for Pharmacoeconomics and Outcomes Research Milan, Italy | November 7–11 2015 Conclusions Objective The Role of Education in the Management of Type 1 Diabetes Mellitus in England Courtney Toth,1 William Marsh,1 Gavin Stewart,1 Lisa Yang,1 Harriet Bridges,2 Jeanette Kusel1 1Costello Medical Consulting Ltd, Cambridge, UK; 2Employee at Costello Medical Consul...

The mechanism(s) of insulin resistance in non-insulin-dependent diabetes mellitus remains ill defined. The current studies sought to determine whether non-insulin-dependent diabetes mellitus is associated with (a) a delay in the rate of onset of insulin action, (b) impaired hepatic and extrahepatic kinetic responses to insulin, and (c) an alteration in the contribution of gluconeogenesis to hep...

Diabetes mellitus, specifically type 2 diabetes, is one of the major public health issues facing the world in the 21st Century. This article summarizes the rapid changes in the management of diabetes and its impact on dental practice. The reader will find many "hyperlinks" to other diabetes information on the Internet throughout this article as these links provide greater detail. The incidence ...

For decades, exercise has been considered a cornerstone of diabetes management, along with diet and medication. However, high-quality evidence on the importance of exercise and fitness in diabetes was lacking until recent years. The last American Diabetes Association (ADA) technical review of exercise and type 2 diabetes (formerly known as non–insulin dependent diabetes) was published in 1990. ...

Wolfram syndrome is the constellation of juvenile onset diabetes mellitus and optic atrophy, known as DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness).Patients demonstrate diabetes mellitus followed by optic atrophy in the first decade, diabetes insipidus and sensorineural deafness in the second decade, dilated renal outflow tracts early in the third decade, and mult...

Asians from the Indian subcontinent have received greater attention in diabetes studies because of their migration in large numbers. The prevalence of non-insulin-dependent diabetes mellitus (NIDDM) in migrant Indians is higher than that in the population residing in the Indian subcontinent and is also usually higher than in the other racial groups in the host country. However, before drawing a...

Type 1 diabetes mellitus (type 1 diabetes, insulin-dependent diabetes mellitus), one of the most common chronic diseases in childhood, is caused by insulin deficiency following autoimmune destruction of the pancreatic beta cells. Until the one and only therapeutic option – the life-long supplementation of insulin or its analogues – was established, affected children died within a short time. Al...