The avian auditory brain stem consists of a network of specialized nuclei, including nucleus laminaris (NL) and superior olivary nucleus (SON). NL cells show sensitivity to interaural time difference (ITD), a critical cue that underlies spatial hearing. SON cells provide inhibitory feedback to the rest of the network. Empirical data suggest that feedback inhibition from SON could increase the I...

FLT3-ITD and FLT3-TKD are the most frequent tyrosine kinase mutations in acute myeloid leukemia (AML), with the former associated with poor prognosis. Here, we show that the PI3K inhibitor GDC-0941 or the Akt inhibitor MK-2206 induced apoptosis through the mitochondria-mediated intrinsic pathway more efficiently in hematopoietic 32D cells driven by FLT3-TKD (32D/TKD) than FLT3-ITD (32D/ITD), wh...

This paper presents a new method of zero-crossing based binaural mask estimation for sound segregation under the condition that multiple sound sources are present simultaneously. The masking is determined by the estimated sound source directions using the spatial cues such as inter-aural time differences (ITDs) and inter-aural intensity differences (IIDs). In the suggested method, the estimatio...

heavy metals in the surface sediments of the two coastal ecosystems of cochin, southwest india were assessed. the study intends to evaluate the degree of anthropogenic influence on heavy metal concentration in the sediments of the mangrove and adjacent estuarine stations using enrichment factor and geoaccumulation index. the inverse relationship of cd and zn with texture in the mangrove sedimen...

BACKGROUND All-trans retinoic acid (ATRA)/anthracycline chemotherapy is beneficial in newly diagnosed acute promyelocytic leukemia (APL); however, it is important to identify patients with high-risk disease to increase the cure rate. We investigated the outcome of ATRA/anthracycline chemotherapy and clinicobiological correlations of FLT3/ITD and NPM1 mutations in APL patients. METHODS Inducti...

This paper investigates the role of the central nucleus of the barn owl's inferior colliculus in determination of the soundsource azimuth. The central nucleus contains many neurons that are sensitive to interaural time difference (ITD), the cue for azimuth in the barn owl. The response of these neurons varies in a cyclic manner with the ITD of a tone or noise burst. Response maxima recur at int...

Interaural time differences (ITD) occur when a binaural signal is delayed at one ear. They arise when a sound is presented outside of the median plane of a subject. In modulated sounds like speech, ITD is present in both the rapidly varying fine structure and the slowly varying envelope. There is evidence that ITD in the fine structure of a sound is most important for sound localization and for...

FLT3 is a receptor tyrosine kinase involved in the proliferation and differentiation of hematopoietic stem cells. FLT3 internal tandem duplications (FLT3/ITDs) are reported in acute myeloid leukemia (AML) and predict poor clinical outcome. We found FLT3/ITDs in 11.5% of 234 children with de novo AML. FLT3/ITD-positive patients were significantly older and had higher percentages of normal cytoge...

About 30% of patients with acute myeloid leukemia (AML) harbour mutations of the receptor tyrosine kinase FLT3, mostly internal tandem duplications (ITD) and point mutations of the second tyrosine kinase domain (TKD). It was the aim of this study to comprehensively analyze clinical and functional properties of various FLT3 mutants. In 672 normal karyotype AML patients FLT3-ITD, but not FLT3-TKD...

UAV laser scanning (ULS) has the potential to support forest operations since it provides high-density data with flexible operational conditions. This study examined use of ULS systems estimate several tree attributes from an uneven-aged northern hardwood stand. We investigated: (1) transferability raster-based and bottom-up point cloud-based individual detection (ITD) algorithms data; (2) auto...