OBJECTIVE Genome-wide association studies (GWAS) have identified genetic variants within multiple risk loci as predisposing to intestinal inflammatory diseases, including Crohn's disease, ulcerative colitis and coeliac disease. Most risk variants affect regulation of transcription, but a critical challenge is to identify which genes and which cell types these variants affect. We aimed to charac...

INFLAMMATORY BOWEL DISEASES AND AIR POLLUTION (Abstract). Air pollution is responsible for the increase in mortality, morbidity and a high number of hospitalizations for respir atory and cardio-vascular diseases. Recently, several studies have shown that air pollution can also affect the digestive system. The major impact was observed on inflammatory bowel diseases (Crohn’s disease and ulcerati...

Abstract Gastrointestinal mucosa forms a surface that interacts with many external factors. Beside the digestion and absorption of nutrients, it also acts as barrier to allergens, pathogens, toxins. Leaky gut syndrome is defined mucosal dysfunction, which results in abnormally increased intestinal permeability. Research shows leaky (LGS) has pathogenetic relationship series gastrointestinal ext...

Abundant data have incriminated intestinal bacteria in the initiation and amplification stages of inflammatory bowel diseases. However, the precise role of intestinal bacteria remains elusive. One theory has suggested a breakdown in the balance between putative species of "protective" versus "harmful" intestinal bacteria--this concept has been termed "dysbiosis". Arguments in support of this co...

abstract intestinal parasitic infections are among the most important infectious diseases that are associated with individual and public hygiene. every year millions of people are infected with some sort of intestinal parasites worldwide. in iran there are different types of intestinal parasites that cause economic, social, and health losses. the aim of the cross-sectional study was to investig...

background although the number of infectious diseases has sharply decreased in last few decades, parasitic diseases persist in developing countries. on the other hand, chronic psychiatric patients tend to have low self-control, poor personal hygiene, long term institutionalization and extremely low self-care should be monitored for parasitic diseases since psychosocial conditions can contribute...

Chronic intestinal pseudo-obstruction is a rare intestinal motility disorder. It is characterized by recurrent or persistent findings of intestinal obstruction in the absence of any mechanical obstruction. Various systemic or congenital diseases are held responsible in the etiology; moreover, it is accepted as idiopathic upon failure of detection of a true reason. We present hereby two rare cas...

stimulate to further effort towards attempting the solution of the many etiological puzzles which, more especially in tropical diseases, still remain unsolved. Among other tropical diseases, the various affections whose leading symptom is intestinal flux, and which are included under the somewhat elastic names of dysentery, sprue, chronic diarrhoea, colitis, entero-colitis, etc., are, perhaps, ...

Metabolic diseases such as obesity are characterized by a subclinical inflammatory state that contributes to the development of insulin resistance and atherosclerosis. Recent reports also indicate that (i) there are alterations of the intestinal microbiota in metabolic diseases and (ii) absorption of endogenous endotoxins (namely lipopolysaccharides, LPS) can occur, particularly during the dige...

Intestinal epithelial cells (IECs) form a physiochemical barrier that separates the intestinal lumen from the host's internal milieu and is critical for electrolyte passage, nutrient absorption, and interaction with commensal microbiota. Moreover, IECs are strongly involved in the intestinal mucosal inflammatory response as well as in mucosal innate and adaptive immune responses. Cell death in ...