Established rheumatoid arthritis (RA) is associated with a doubled cardiovascular risk. However, data about the cardiovascular risk in early RA are scarce. Preclinical atherosclerosis can be reliably assessed with the carotid intima media thickness (cIMT), and the cIMT is a well-validated predictor of cardiovascular events. The cIMT was therefore used in a recent controlled, prospective study i...

one of the locations of renal artery atherosclerosis is at the orifice of the renal artery, therefore thestructure of this orifice was assessed in 6 normal, adult male dogs by light microscopy (lm) andtransmission electron microscopy (tem). for the lm study, processed tissues were embedded in paraffinand sectioned serially into 6-μm thickness. sections were stained with orcein. for the tem stud...

conclusions our study shows a relationship between cimt and renal parameters, including egfr and albuminuria. this study confirms the importance of intensive examinations for early detection of atherosclerosis and treatment of risk factors. patients and methods this cross-sectional study was included 205 patients with type 2 diabetes mellitus (t2dm). we recorded clinical and biochemical data su...

BACKGROUND/AIMS Helicobacter pylori infection has been suggested to be associated with atherosclerosis. The issue is still controversial. It is well known that abnormal lipid profile and oxidative stress are related to atherosclerosis and the measurement of carotid intima-media thickness. The aim of this study was to investigate carotid intima-media thickness and oxidative stress along with lip...

BACKGROUND Using new, very high-resolution ultrasound biomicroscopy, we examined the thickness of artificial layers of silicone and intima thickness (IT) of radial and anterior tibial arteries in healthy subjects and in patients with vascular disease. METHODS AND RESULTS Silicone layers of varying thicknesses and mesenteric artery specimens obtained from 18 patients undergoing colectomy were ...

OBJECTIVE Natriuretic peptide receptor-C (NPR-C/NPR-3) is a cell surface protein involved in vascular remodelling that is up-regulated in atherosclerosis. NPR-C expression has not been well characterized in human carotid artery occlusive lesions. We hypothesized that NPR-C expression correlates with intimal features of vulnerable atherosclerotic carotid artery plaque. METHODS To test this hyp...

Cerebral aneurysm is a common disease with a high prevalence and can cause a catastrophic subarachnoid hemorrhage. To elucidate the molecular mechanism of the formation and progression of cerebral aneurysms, gene expression profiling was performed in experimentally induced rat cerebral aneurysms. The intima and media of cerebral arterial walls in rats with or without aneurysm induction were dis...

OBJECTIVE To investigate carotid intima-media thickness (IMT) and serum endothelial marker levels in obese Chinese children. DESIGN Observational and descriptive study. SETTING Hangzhou, China. PARTICIPANTS A total 131 obese children, including 29 with at least 2 components of metabolic syndrome (MS) (MS group), 102 with less than 2 components of MS (obese group), and 31 nonobese children...

Intima-media thickness of the common carotid arteries is a marker of atherosclerosis and has been shown to be associated with prevalent and incident coronary heart disease and with coronary heart disease risk factors. The authors examined the association of baseline risk factors or change in risk factors with change in intima-media thickness over follow-up (1987-1998) in the Atherosclerosis Ris...

The goals of this study were to determine whether vasa vasorum in atherosclerotic coronary arteries respond to vasoactive stimuli and to examine effects of regression of atherosclerosis on blood flow through vasa vasorum in coronary arteries. We studied three groups of monkeys: normal, atherosclerotic, and regression. Blood flow to vasa vasorum was measured with microspheres. Blood flow to inti...