OBJECTIVES To elucidate characteristics in generation-to-generation TB transmission from smear positive pulmonary TB patients. SUBJECTS AND METHODS The subjects of this retrospective study were 10,088 TB patients registered in Aichi prefecture between 1989 and 2003. Smear-positive pulmonary TB was found in 3,332. All registration files were reviewed to identify epidemiological links of patien...

Schwannomatosis is a form of Neurofibromatosis type 2 (NF2) characterized by multiple schwannomas without vestibular involvement, affecting the cranium, spine and periphery. Several recent genetic studies have implicated the SMARCB1/INI1 tumour suppressor gene in familial schwannomatosis. SMARCB1 is located centromeric to NF2 on 22q and loss of function of SMARCB1 is also a hallmark of malignan...

Most mature students of human personality are agreed that normal and abnormal characteristics are determined by the complex interaction of numerous biological (e.g. genetic, neuro-endocrine, or metabolic), psychological, social, and cultural factors (Kluckhohn, Murray, and Schneider, 1953). However, there still exist wide differences of opinion as to the relative importance of various determina...