Intracameral tissue plasminogen activator (t-PA) application in a child with previously unrecognized sickle cell anemia, post-traumatic hyphema, thrombosis in trabecular mashwork and consecutive acute glaucoma showed positive results. Thirteen year-old boy, son of African father and Caucasian mother, was admitted to hospital, with symptoms of acute glaucoma and partial hyphema after right eye t...

PURPOSE The objective of this study is to evaluate whether a phenylephrine and ketorolac injection 1%/0.3% (phenyl/keto injection) (Omidria®) prior to capsulotomy decreases the need for the Malyugin Ring® to manage small pupils. SETTING Bucci Laser Vision Institute, Wilkes-Barre, PA, USA. DESIGN Retrospective analysis of cataract surgeries performed by a single surgeon at a single center. ...

AIM: To evaluate whether a novel tyrosine kinase inhibitor nintedanib could inhibit basic fibroblast growth factor (bFGF) and vascular endothelial (VEGF) simultaneously for retinal disease in vivo. METHODS: After laser induced rabbit vein occlusion (RVO) model was made, 0.5 mg of injected intravitreally the left eye on third day while right as control. Intracameral samples were taken before tre...

PURPOSE To describe prophylactic patterns employed against endophthalmitis after cataract surgery in Iran. METHODS This cross-sectional study included 486 ophthalmologists filling in a self-administered questionnaire during the 20(th) Annual Congress of the Iranian Society of Ophthalmology in December 2010, Tehran, working in both private and academic medical centers. Prophylactic measures us...

Inoculation of P815 tumor cells into the anterior chamber of eyes of BALB/c mice produces Anterior Chamber Associated Immune Deviation (ACAID) whereby delayed hypersensitivity responses to the minor H antigens of the tumor cells are suppressed. In our laboratory, impaired delayed hypersensitivity is obtained in the majority, but not all normal BALB/c recipients. In the minority, typcial delayed...

PURPOSE The present experimental study aimed to investigate the effects of intracameral trypan blue (TB) on oxidative stress parameters and apoptosis in corneal tissue. METHODS Thirty rats were randomly assigned to three groups of 10 rats each: the sham group (Group 1); control group (Group 2); and treatment group (Group 3). The control group was administered 0.01 cc of balanced salt solution...

PURPOSE To determine the effect of latrunculin (LAT)-A, which binds to G-actin and disassembles actin filaments, on the pupil, accommodation, and isolated ciliary muscle (CM) contraction in monkeys. METHODS Pupil diameter (vernier calipers) and refraction (coincidence refractometry) were measured every 15 minutes from 0.75 to 3.5 hours after topical LAT-A 42 microg (approximately 10 microM in...