This study was designed to investigate the effects of a growing H6 hepatoma on the intracellular element content in three distinctly different tissue cell populations of the mouse host (hepatocytes, fibroblasts, and crystal enterocytes). X-ray microanalysis measurements of the intranuclear concentrations of several elements (sodium, magnesium, phosphorus, sulfur, chlorine, and potassium) were m...

The present study was undertaken to evaluate the effects of lansoprazole (LPZ) on lipopolysaccharide (LPS)-stimulated toll-like receptor 4 (TLR4) signal transduction systems using the 293hTLR4/MD2-CD14 cells. The cells were incubated and then divided into the following groups: (a) untreated group, (b) non-LPZ treated (1h) group, (c) LPZ-treated (1h) plus non LPS-stimulated (1h) group, (d) LPZ-t...

We have isolated and partially characterized a major intranuclear matrix polypeptide from rat liver. This polypeptide, which is reversibly stabilized into the intranuclear matrix under conditions which promote intermolecular disulfide bond formation, has a Mr of 62,000 and pI of 6.8-7.2 as determined by two-dimensional IEF/SDS-PAGE. A chicken polyclonal antiserum was raised against the polypept...

The relationship between the pathophysiology of osteoarthritis (OA) and metabolic disorders (metabolic syndrome, obesity) is provided not only by mechanical causes (increased body weight pressure on joints). A complex molecular mechanisms, which mediates OA effect development obesity, was established. Excessive activity toll receptors, NF-κB cascade, endogenous chondroitin sulfates (CS) lead to...

Intranuclear inclusionsof cytomegalovirus infections were first noticed in 1881 by Ribbert5 who thought they represented protozoa, He saw large cells in sections of the kidney of a luetic stillborn and in the parotid gland of children.5 In 1907 Lòwenstein6 found such cells in the parotid glands of 4 out of 30 infants. These appear to be the first descriptions of typical cytomegalic cells with i...

Here, we present a case of anaplastic giant cell ependymoma (GCE) occurring in a 15-year-old woman. Squash smear slides for intraoperative frozen section diagnosis revealed oval to round cell clusters with a papillary structure in a fibrillary background. This was occasionally accompanied by the presence of bizarre pleomorphic giant cells with hyperchromatic nuclei and prominent intranuclear in...

In this paper, we describe the identification and characterization of two novel and essential mitotic spindle proteins, Duo1p and Dam1p. Duo1p was isolated because its overexpression caused defects in mitosis and a mitotic arrest. Duo1p was localized by immunofluorescence, by immunoelectron microscopy, and by tagging with green fluorescent protein (GFP), to intranuclear spindle microtubules and...

Background: Infertility, defined by the failure to achieve a clinical pregnancy after twelve months or more of regular unprotected sexual intercourse. infertility is an important health problem in the society .tubal pathology is one of the main causes of infertility.it is estimated to account for 12-33%.hysterosalpingography is a method used for screening purposes in the routine infertility eva...