Styrene-specific N-7- and O6-guanine DNA adducts and N-terminal valine adducts were determined in mice tissues after the intraperitoneal administration of styrene. Blood, liver, lungs and spleen were collected 3 h after administration of various doses (from 0 to 4.35 mmol/kg b.w.) of styrene. DNA adducts were analysed by the modified 32P-postlabelling assay and N-terminal valine adducts were de...

The athrocytosis of hemoglobin by the epithelium of the proximal convoluted tubules in the kidney of the rat was studied after its intraperitoneal injection, absorption into the blood stream, and glomerular filtration. The earliest appearance of the athrocytosed particles, their accumulation, intracellular breakdown, and disappearance were followed. In addition observations were made on the int...

A defined pollen extract of selected plants has been reported to possess some pharmacological activities on chronic prostatitis or benign prostatic hyperplasia. This paper describes the antitumour potential of the water-soluble fraction (Cernitin T60) of the pollen extract against Lewis lung carcinoma implanted intraperitoneally in syngeneic mice. Cernitin T60 was not cytotoxic in cell cultures...

The distribution of uranium in mice following intravenous and intraperitoneal injections of uranyl nitrate and uranyl tricarbonate was studied by autoradiographic and fluorometric methods at different times after administration. The investigations revealed a higher retention of uranium in the spleen and bone than in other organs, including the kidneys. We have been able to show that even very s...

Intraperitoneal transplantation of encapsulated islets can restore normoglycemia in diabetic recipients but not normal glucose tolerance nor normal insulin responses to a physiological stimulus. This study investigates whether the intraperitoneal implantation site as such contributes to the interference with optimal transport kinetics between the islets and the bloodstream. Insulin was infused ...

Bisphenol-A is an estrogenic chemical used today in the production of epoxy resin and as additive other non-polymer plastics. Due to widespread use BPA today, human exposure inevitable. This causes harmful effects on various body systems. The aim this study investigate development kidneys offspring mother rats exposed during pregnancy lactation, a result being through placenta milk. In study, 1...

Background: Laparoscopy is an established method to perform major surgeries, with many advantages over open surgeries. Hysterectomy a common procedure performed increased use of laparoscopy, having postoperative pain management issue. Effective promotes early ambulation, lowering the risk DVT and PE.Methods: The present study aimed assess effect bupivacaine intraperitoneally during laparoscopic...

BACKGROUND Local anaesthetics (LA) injected intraperitoneally have been found to decrease postoperative pain. This double-blind randomized study was performed comparing continuous infusion or patient-controlled intraperitoneal (i.p.) bolus injection of LA. The primary endpoint was supplemental opioid consumption during the first 24 postoperative hours. METHODS Two multi-hole catheters were pl...