We have previously shown that injection of anti-glycoprotein (GP) IIb induces murine immune thrombocytopenia (ITP) and that intravenous immunoglobulin (IVIg) ameliorates ITP. We hypothesise that murine ITP may be associated with platelet apoptosis, which is upregulated by anti-GPIIb and downregulated by IVIg. The current study demonstrated that anti-GPIIb injection induced three critical apopto...

Recurrent pericarditis is a troublesome complication of idiopathic acute pericarditis and occurs more frequently in pediatric patients after cardiac surgery (postpericardiotomy syndrome). Conventional treatment with nonsteroidal antiinflammatory drugs, corticosteroids, and colchicine is not always effective or may cause serious adverse effects. There is no consensus, however, on how to proceed ...

SIR-The recent paper by Glatt and Anand [1] provides an excellent, comprehensive review of the natural history and treatment options with regard to HIV-related thrombocytopenia. We wish to discuss the efficacy of therapy with intravenous anti-rhesus D (Rho[D]) immunoglobulin in this setting. Glatt and Anand state that the drawbacks to intravenous anti-RHo(D) include lack of experience with its ...

We describe the case of a 48-year-old man with dermatomyositis (DM) who demonstrated rapidly progressive interstitial lung disease (RP-ILD) and refractory cutaneous involvement together with high levels of anti-melanoma differentiation-associated gene 5 antibody (anti-MDA5-Ab). Even after combination immunosuppressive therapy including a corticosteroid, cyclosporine A, and intravenous cyclophos...

Myasthenic crisis is a life-threatening condition. At times it manifests as the initial presentation of underlying myasthenia gravis. Rapidly acting therapies for treatment this condition are plasma exchange and intravenous immunoglobulin. We report case myasthenic in young female, presenting with respiratory failure bulbar symptoms. She had significantly raised titres anti-acetylcholine recept...