six mixed-breed apparently healthy dogs were intravenously administered a single dose of tetracycline hydrochloride (50 mg/kg) to evaluate the pharmacokinetic parameters of the drug. blood samples were collected before and at various time intervals after the administration of the drug. serum tetracycline concentrations were determined over a 24 h period using fluorescence spectrophotometry. non...

The manner in which a single injection of S. typhosa endotoxin effects the primary hemolysin response to sheep erythrocytes in the mouse has been shown to depend on the dosage, route, and time of administration of the endotoxin, as well as on the route employed for the injection of antigen. The normal production of antibody, following an intravenous or an intraperitoneal injection of red blood ...

We studied the effect of fentanyl pretreatment on alleviating pain during the injection of Propofol-Lipuro. One hundred and seventy patients were randomly allocated to receive either 100 mcg of intravenous fentanyl or normal saline (placebo) followed by intravenous Propofol-Lipuro premixed with 20 mg lignocaine. The incidence of injection pain was 32% and 13% in the placebo and fentanyl groups,...

objectives: to investigate the effects of intravenous infliximab in preventing the formation of peritoneal adhesions in an animal model of rat. methods: this was an experimental study being performed in animal laboratory of shiraz university of medical sciences during 2012. sixty albino rats were randomly assigned in to three groups by random design method. the first group received single infli...

OBJECTIVES Mountain ginseng pharmacopuncture (MGP) is an extract distilled from either mountain cultivated ginseng or mountain wild ginseng. This is the first intravenous injection of pharmacopuncture in Korea. The word intravenous does not discriminate between arteries, veins, and capillaries in Oriental Medicine, but only the vein is used for MGP. The aim of this study is to evaluate the intr...

Salmonella typhimurium double leu-arg auxotrophs have been shown to be highly effective as antitumor agents in nude mouse models of human metastatic cancer. In order to proceed to clinical development of the S. typhimurium double auxotroph, termed A1-R, it is necessary to evaluate antitumor efficacy in immunocompetent mice. In the present study, we have observed the efficacy of A1-R on the Lewi...

BACKGROUND Propofol, an intravenous anesthetic, often causes pain on injection, which can be very distressful to patients. We investigated the analgesic effect of pregabalin on pain following propofol injection, compared with lidocaine. METHODS In a randomized, double-blind, prospective trial, 120 patients were randomized into 3 groups of 40 each; who received oral placebo and intravenous lid...

We have already reported 1 the results of our studies with subcutaneous injections of immune serum in spirocha~tosis icteroh~emorrhagica. In the present article are presented the results of injections made by the intravenous method, which has in the main been employed in the serotherapy of Weil's disease since May, 1916. The number of patients treated in this manner in our clinic from May, 1916...

The effects of 1) a rapid intravenous injection of insulin (4.4 IU), 2) a continuous intravenous infusion of insulin (.14 IU/min), or 3) a rapid intravenous injection of glucose (.24 g/kg body weight) into nonpregnant ewes and 4) a continuous intravenous infusion of glucose (1.2 mg/kg body weight/rain) into pregnant ewes on plasma amino acid metabolism and a-amino acid nitrogen (~-NH 2 -N) upta...

abstract background: providing better surgical conditions with meticulous control of intraocular pressure (iop) is one of the most important factors that affect the success rate in ophthalmic surgery. clonidine is a selective central α2 agonist with analgesic, antianxiety and sedative effects which makes it a good choice in premedication recently. in this study, we compared the effects of oral ...