statement of the problem: premedication is expedient in reducing the psychological trauma from recalling the unpleasant pre-anesthetic phases, hence, inducing a trouble-free anesthesia. purpose: this study aimed to determine the effectiveness of oral midazolam in co-operation of the subjects before general anesthesia and in recalling the pre-anesthetic phases, performed on children candidate fo...

BACKGROUND Midazolam has analgesic properties. The aim of the present study was to assess the analgesic effect of midazolam when added to lidocaine in intravenous regional anesthesia (IVRA). METHODS Sixty patients undergoing hand surgery were randomly allocated into two groups to receive 3 mg/kg 2% lidocaine diluted with saline to a total volume of 40 mL in the control group (group lidocaine ...

A 38-year-old man presented to our emergency room with severe pain and inability mobilize his right shoulder joint after a violent blunt trauma during work. The humeral head was palpable anteriorly, the loss of normal contour deltoid acromion prominent posteriorly laterally, as it occurs in anterior dislocation. easily reduced on 1st attempt using 1.5 mg/kg intravenous fentanyl 0.5 mg/Kg midazo...

Objective: The key objective of the study is to compare Propofol-based total intravenous anaesthesia (TIVA) with Isoflurane-based inhalational for controlled hypotension during functional endoscopic sinus surgery (FESS). Materials and Methods: This a prospective randomized, single-blinded clinical study. involved 40 patients posted elective FESS surgery, selected randomly from ENT department. A...

BACKGROUND Sevoflurane and ketamine are commonly used to obtain sedation and facilitate intravenous anesthetic induction in children undergoing cardiac surgery who are uncooperative. We used a new and direct systemic hemodynamic monitoring technique pressure recording analytical method and compared the hemodynamic effects of sevoflurane and ketamine to facilitate intravenous anesthetic inductio...

Daily rhythms in physiology may affect the pharmacokinetics of a drug. The aim of this study was to evaluate 24-hour variation in the pharmacokinetics of the CYP3A substrate midazolam. Oral (2 mg) and intravenous (1 mg) midazolam was administered at six timepoints throughout the 24-hour period in 12 healthy volunteers. Oral bioavailability (population mean value [RSE%] of 0.28 (7.1%)) showed 24...

background: paradoxical reactions to benzodiazepines including restlessness, anxiety and sometimes violent behavior sometimes occur. most of the known predicting factors of disinhibitory reactions such as age, gender, genetic or the psychological backgroundare not modifi able. th is study was conducted to evaluate the eff ect of rate of midazolam administration, as a controllable factor, on the...