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The focus of this study was to determine if early detection of mutant p53 accumulation may be an early indicator of tumor aggressiveness and transformation to invasive breast cancer. For this purpose, the p53 content of 100 human breast biopsies classified as ductal carcinoma (DCIS), was evaluated by immunohistochemical method. All specimens were microscopically classified into histologic types...

with the rapid development of the internet, the amount of information and data which are produced, are extremely massive. hence, client will be confused with huge amount of data, and it is difficult to understand which ones are useful. data mining can overcome this problem. while data mining is using on cloud computing, it is reducing time of processing, energy usage and costs. as the speed of ...

invasive meningococcal disease (imd) is a severe bacterial infectious disease with high mortality and morbidity rates worldwide. in recent years, industrialised countries have implemented vaccines targeting imd in their national immunisation programmes (nips). in 2002, the netherlands successfully implemented a single dose of meningococcal serogroup c conjugate vaccine at the age of 14 months a...

background conservative surgical treatment has been the treatment of choice for early breast cancer. it allows feasible oncological treatment with a satisfactory cosmetic approach and fast recovery. however, in some cases mastectomy is necessary. this study proposes a surgical approach with only one surgical access through the same incision, which is in line with precepts mentioned above. it is...

ardekoul fault zone which is along nnw-sse is located in eastern iran and northern part of the sistan subzone. dextral strike-slip fault zone of ardekuol is made of six main segments including korizan (28 km), bohn abad (8.8 km), abiz (32 km), gazkoon (20 km), moein abad (30.4 km), ghal maran (12 km), and two minor segments including olang morgh (12.8 km) and seh pestan (9.6 km).  the studied r...

chronic granulomatous disease is an inherited defect in intracellular killing of ingested microorganisms characterized by recurrent life threatening bacterial and fungal infections including invasive aspergillosis in early childhood. we report  a  disseminated aspergillosis as  the  representative  of  adult  onset  chronic granulomatous disease without previous infection, with dramatic respons...

conclusions the rate of ifis in pediatric patients with hematologic disorders is high, and sample collection from the sterile sites cannot be performed in immunocompromised patients. detection of circulating fungal cell wall components and dna in the blood using non-invasive methods can offer diagnostic help in patients with suspected ifis. their results should be interpreted in combination wit...

conclusions the incidence of ipa in allogeneic hsct and patients with hematological malignancies was relatively high and a. flavus was the most common cause of pa. as molecular methods had higher sensitivity, it may be useful as screening methods in hsct and patients with hematological malignancies, or to determine when empirical antifungal therapy can be withheld. results seven (15.2%) out of ...