1 Faculty of Chemistry and Pharmacy, University of Innsbruck, Innrain 52a, 6020 Innsbruck, Austria; Phone: +43 512 507 5118; Fax: +43 512 507 2934; E-mail: [email protected] 2 Competence Centre for Wood Composites and Wood Chemistry K-Plus, St.-Peter-Str. 25, 4021 Linz, Austria 3 Institute of Mineralogy and Petrography, University of Innsbruck, Innrain 52, 6020 Innsbruck, Austria...

Ionic motion through an open ion channel is analyzed within the framework of selfconsistent Brownian dynamics. A novel conceptual model in which the ions motion is coupled to the vibrations of the pore walls is introduced. The model allows to include into simulations an important additional mechanism of energy dissipation and the effects of self-induced strong modulation of the channel conducti...

(1.1) Cm ∂V ∂t = 1 Ra ∂2V ∂x2 − Iion(V, t)− Istim(t), where Ra and Cm are the axial resistance and membrane capacitance, Iion represents the total ionic current, and Istim(t) is an applied stimulus current which instigates an action potential. The source term Iion is usually specified by some Hodgkin-Huxley type ionic model. In our simulations, we use the Luo-Rudy phase I (1991) model, one of t...

In the last two decades, while searching for interesting applications of ionic liquids as potent solvents, their solvation properties and their general impact on biomolecules, and in particular on proteins, gained interest. It turned out that ionic liquids are excellent solvents for protein refolding and crystallization. Biomolecules showed increased solubilities and stabilities, both operation...

Abnormalities in repolarization and its rate dependence are known to be related to increased proarrhythmic risk. A number of repolarization-related electrophysiological properties are commonly used as preclinical biomarkers of arrhythmic risk. However, the variability and complexity of repolarization mechanisms make the use of cellular biomarkers to predict arrhythmic risk preclinically challen...

BACKGROUND Endogenous electric fields and currents occur naturally at wounds and are a strong signal guiding cell migration into the wound to promote healing. Many cells involved in wound healing respond to small physiological electric fields in vitro. It has long been assumed that wound electric fields are produced by passive ion leakage from damaged tissue. Could these fields be actively main...

Liquid metal salts are electrolytes with the highest possible metal concentration for electrodeposition, because the metal ion is an integral part of the solvent. This paper introduces the new ionic silver complexes [Ag(MeCN)(4)](2)[Ag(Tf(2)N)(3)], [Ag(MeCN)][Tf(2)N] and [Ag(EtIm)(2)][Tf(2)N], where MeCN stands for acetonitrile, EtIm for 1-ethylimidazole and Tf(2)N is bis(trifluoromethylsulfony...

We describe voltage- and calcium-dependent ionic currents in the photoreceptor inner segments similar to the Hodgkin and Huxley (Journal of Physiology, 117, 500-544, 1952) equations. The model is used to describe both rods and cones by adjusting parameters. To simulate the light response, the inner segment model was connected with the phototransduction model proposed by Torre et al. (Cold Sprin...

The concepts, experiments, and interpretations of ionic current measurements after a step change of the squid axon membrane potential require the potential to be constant for the duration and the membrane area measured. An experimental approach to this ideal has been developed. Electrometer, operational, and control amplifiers produce the step potential between internal micropipette and externa...

The modification of glass nanopipettes with polyethyleneimines (PEIs) has been successfully achieved by a relatively simple method, and the smallest tip opening is around 3 nm. Thus, in a much wider range of glass pipettes with radii from several nanometers to a few micrometers, the ion current rectification (ICR) phenomenon has been observed. The influences of different KCl concentrations, pH ...