The results of genome-wide association studies (GWAS) indicate that most complex diseases are highly polygenic: (1) associated alleles typically have small effect sizes, (2) the number of significant associated alleles has continued to increase with increasing sample size, and (3) genome-wide methods such as random effects models have detected much greater total genetic effects than accounted f...

Before the outbreak of COVID-19, case Barcelona was an emblematic example how a city had turned into iconic tourism destination in few decades thanks to smart, yet incautious, development policies based on most attractive features is endowed with. The paper critical reflection analyzing major complications, called “tsunamis”, has faced recent years: political instability, terrorism and tourismo...

Lactoferrin is a glycoprotein present in most human mucosal secretions, including human milk. Lactoferrin is bacteriostatic in low iron media and, in some settings, bactericidal. Lactoferrin impairs ability of Shigella flexneri serotype 5 strain M90T to invade HeLa cells. To determine the mechanism by which lactoferrin decreases invasiveness of Shigella organisms, its effect on the major virule...

In this research seismicity parameters, repeat times and occurrence probability of large earthquakes are estimated for 35 seismic lineaments in Persian plateau and the surrounding area. 628 earthquakes of historical time and present century with MW>5.5 were used for further data analysis. A probabilistic model is used for forecasting future large earthquake occurrences in each chosen lineament....

shigella and escherichia belong to the enterobacteriaceae family which are the cause for most of the diarrheal cases in the world. shigella can cause bacterial dysenteries and shigellosis. one of the most effective proteins for pathogenesis is invasion plasmid antigen c (ipac). other bacteria like enterotoxogenic (etec), enterohemorrhagic (ehec), and e.coli can also cause diarrhea and produce i...