INTRODUCTION The LMNA gene encodes a group of proteins that have an important structural and functional role in the cell nucleus. Mutations in this gene have been found in 6% of all forms of dilated cardiomyopathy and in up to 33% of those with conduction system disturbances. AIMS AND METHODS Using a case report as an example, we performed a review of the literature on the pathophysiological ...

Cardiac resynchronization therapy (CRT) is a new treatment for refractory heart failure. However, most patients with heart failure treated with CRT are adults, middle-aged or older with idiopathic or ischemic dilated cardiomyopathy. We treated a 12-year-old boy, who was transferred after cardiac arrest, with dilated cardiomyopathy, left bundle-branch block, and ventricular tachycardia. We perfo...

Dilated cardiomyopathy can be broadly defined as heart failure with an enlarged left ventricular chamber, but with no evidence of ischemic heart disease or myocardial infarction. Recent studies from patients and animal models show that dilated cardiomyopathy results in a decrease in myocardial content of adenosine-50-triphosphate (ATP) and phosphocreatine and a decrease in the capacity for mito...

The expression of adrenomedullin (AM) and atrial natriuretic factor (ANF) were investigated in the myocardium of a rat model of chronic ischemic heart failure (CHF) compared with sham-operated controls. In addition, human myocardium of patients with end-stage heart failure due to idiopathic dilated cardiomyopathy compared with myocardium of normal subjects (NF) was studied. In CHF, similar AM l...

The patient was a 31-year-old man with a past history of polycythemia vera, “enlarged heart” (1992), transient ischemic attack (1995), and decompensated heart failure (1997). He was referred for evaluation and management of suspected dilated cardiomyopathy. An ECG demonstrated Q waves in the anterolateral leads. Cardiac catheterization was performed. The image shown is a posteroanterior cranial...

Nonischemic dilated cardiomyopathy (NIDCM) is a common cause of congestive heart failure (CHF) and is a risk factor for sudden cardiac death (1,2). Although an asymptomatic patient with ischemic cardiomyopathy can now be approached with a reasonably established strategy (e.g., risk stratification using an electrophysiologic [EP] study in those with moderately reduced left ventricular [LV] funct...

Ischemic cardiomyopathy is the most common type of dilated cardiomyopathy. Its surgical treatment is one of the most challenging topic in cardiac surgery, with a history starting about 50 years ago. Several types of correction have been devised with varying outcome. The problem of mitral regurgitation is still an open issue. Hundreds of studies tried to resolve the dilemma of the best surgical ...

In this study we performed a next generation sequencing of 210 genes in 140 patients with cardiac failure requiring heart transplantation. We identified total 48 candidate variants 47 patients. Forty-three (90%) presented single variant, and fourpatients (10%) were carriers two variants. After refining the classification, pathogenic or likely variant 13 (10% our cohort). 34 additional cases (25...

BACKGROUND Surgical ventricular restoration is an option in patients with coronary artery disease, heart failure, postinfarction left ventricular aneurysm or ischemic dilated cardiomyopathy with or without ventricular tachycardia. The aims of this study were to investigate survival and re-admission for heart failure and to identify predictors for early and long-term mortality and re-admission a...