We previously identified a novel apoptosis-inducing humoral factor in the conditioned medium of hypoxic/reoxygenated-cardiac myocytes. We named this novel post-translationally-modified secreted-form of eukaryotic translation initiation factor 5A Oxidative stress-Responsive Apoptosis-Inducing Protein (ORAIP). We confirmed that myocardial ischemia/reperfusion markedly increased plasma ORAIP level...

This review focuses on the role of reactive oxygen species (ROS) development type 1 and 2 diabetes its treatment with secoisolariciresinol diglucoside (SDG) isolated from flaxseed which is an antioxidant suppresses phosphoenolpyruvate carboxykinase (PEPCK) gene expression, a ratelimiting enzyme in gluconeogenesis liver. Role ROS [diabetic prone Bio Breeding (BBdp) rats streptozotocin-induced di...

Elevated uric acid causes direct injury to pancreatic β-cells. In this study, we examined the effects of luteolin, an important antioxidant, on uric acid-induced β-cell dysfunction. We first evaluated the effect of luteolin on nitric oxide (NO) formation in uric acid-stimulated Min6 cells using the Griess method. Next, we performed transient transfection and reporter assays to measure transcrip...

BACKGROUND & AIMS Although the cells that contribute to pancreatic regeneration have been widely studied, little is known about the mediators of this process. During tissue regeneration, infiltrating macrophages debride the site of injury and coordinate the repair response. We investigated the role of macrophages in pancreatic regeneration in mice. METHODS We used a saporin-conjugated antibod...

primary pancreatic lymphoma is a rare extranodal manifestation of any histopathologic subtype of b cell non-hodgkin's lymphoma that predominantly involves the pancreas. it comprises less than 0.2% of pancreatic malignancies and less than 0.7% of non-hodgkin's lymphomas. this lymphoma is almost never suspected clinically. it is usually diagnosed by surgical exploration for suspected ad...

Serum amylase and lipase were measured in 32 patients with cerebral ischemia, 19 with spontaneous cerebral hemorrhage, 15 with head injury and intracranial bleeding, and 22 with head injury without intracranial bleeding; 20 healthy subjects were also studied as controls. Serum pancreatic isoamylase concentrations were assayed in hyperamylasemic sera. The overall incidence of hyperamylasemia was...

Sepsis causes multiple-organ dysfunction including pancreatic injury, thus resulting in high mortality. Innate immune molecule surfactant protein D (SP-D) plays a critical role in host defense and regulating inflammation of infectious diseases. In this study we investigated SP-D functions in the acute pancreatic injury (API) with C57BL/6 Wild-type (WT) and SP-D knockout (KO) mice in cecal ligat...

INTRODUCTION Pancreatic injury is uncommon and the management remains controversial. The integrity of the main pancreatic duct is considered the most important determinant for prognosis. CASE PRESENTATION A 19-year-old Greek man was referred to our tertiary referral centre due to blunt abdominal trauma and an associated grade III pancreatic injury. He was haemodynamically stable and his initi...

Acute pancreatitis is a common gastrointestinal disease, most frequently requiring acute hospitalization. During SARS-CoV-2 (severe respiratory syndrome coronavirus-2) pandemic, the etiologic agent of COVID-19, several studies described involvement other tissues besides tract, such as tract. In pancreas, ACE-2 receptor expressed in exocrine glands and islets, both being targets for virus subseq...