Nonhistone proteins fractionated from normal rat liver and Walker carcinosarcoma can stimulate chromatin-templated RNA synthesis in vitro. This has been demonstrated by using RNA polymerase prepared from rat liver. Walker tumor, or Micrococcus lutcus. The RNA isolated from these fractionated nonhistone proteins does not activate transcription from chromatin. As judged by DNA-RNA hybridization s...

A purified compound of the activator of glucuronide formation was isolated from a boiled extract of rat liver by charcoal adsorption, ethanol fractionation of barium salts, and finally paper and Dowex-l column chromatographies. The analytical data and the chemical properties of the compound sugggested that the endogenous activator of glucuronide formation in rat liver might be uridine diphospha...