C100 emerging nascent chain, binds to the large ribosomal subunit in the vicinity of the tunnel opening and forms a sheltered folding space. The 3.5Å crystal structure of the large ribosomal subunit of the eubacterium Deinococcus radiodurans, D50S, in complex with the TF binding domain (TFa) from Deinococcus radiodurans, reveals for the first time the molecular structure of the entire TFa bound...

The benefits of estrogen replacement as a preventative treatment for Alzheimer's disease (AD) are subject to debate. Because the effects of estrogen depletion and replacement on accumulation of the neurotoxic beta-amyloid (A beta) peptide in transgenic animal models of AD have been variable, we examined A beta levels and oxidative stress in a nontransgenic animal model. Sheep have traditionally...

The serologic reactivity and epidemiology associated with different hepatitis C virus (HCV) variants were investigated in a cohort of 113 anti-HCV-positive donors. In Scotland, HCV type 1 accounted for one-half of all infections; 40 percent of subjects were infected with HCV type 3, and the remainder were infected with type 2. Reactivity with the NS-4-encoded antigens in the first-generation an...

26 Fasting is part of penguin’s breeding constraints. During prolonged fasting three 27 metabolic phases occur successively. Below a threshold in body reserves, birds enter phase 28 III (PIII), which is characterized by hormonal and metabolic shifts. These changes are 29 concomitant with egg abandonment in the wild and increased locomotor activity in captivity. 30 Because CORT enhances foraging...

Deficiency in N-linked protein glycosylation is a long-known characteristic of alcoholic liver disease and congenital disorders of glycosylation. Previous investigations of ethanol-induced glycosylation deficiency demonstrated perturbations in the early steps of substrate synthesis and in the final steps of capping N-linked glycans in the Golgi. The significance of the biosynthesis of N-glycan ...

Indeterminate hepatitis C virus (HCV) third-generation recombinant immunoblot assay (RIBA3.0; Ortho Diagnostic Systems) patterns were arbitrarily defined by the manufacturer as the detection of only one antibody out of the four that were sought, namely, c100 (NS4 encoded), c22 (core encoded), c33c (NS3 encoded), and NS5 (NS5 encoded). The aims of the present study were (i) to determine the prev...

Physical and functional properties of nonwoven textiles and other fiberlike materials depend strongly on the number and type of fiber-fiber interactions. For nanoscale polymeric fibers in particular, these interactions are governed by the surfaces of and contacts between fibers. We employ both molecular dynamics (MD) simulations at a temperature below the glass transition temperature T(g) of th...