In this present cardioprotective activity study the crude powder of the Hyoscyamus niger Linn is administered to the male albino rats at the dose of 100mg/100g.b.wt. The markers of cardiac function test assess the normal functioning of heart. If there is a change in their normal values of these makers it indicates the dysfunction of heart. Biochemical parameters like TGL, Ck-MB and LPO were car...

1024x768 normal 0 false false false en-us x-none fa background : heart failure is a common health problem with poor prognosis. the gold standard for diagnosis is echocardiography but it is not always reachable, especially in emergency conditions. nt-pro-brain natriuretic peptide (nt-probnp) is a novel indicator for the diagnosis of heart failure and is being used in routine tests in emergency r...

Though there are studies to show protective effect of glutathione against neurotoxicity and nephrotoxicity, the present study was designed to investigate the cardio protective effect of glutathione against isoproterenol induced myocardial infarction in rats by demonstrating the changes in serum cardiac markers, antioxidant enzymes and ECG changes. Wistar male rats were randomly divided into fou...

We investigated whether deficiency of inducible nitric oxide synthase (iNOS) could prevent isoproterenol-induced cardiac hypertrophy in iNOS knockout (KO) mice. Isoproterenol was continuously infused subcutaneously (15 mg/kg/day) using an osmotic minipump. Isoproterenol reduced body weight and fat mass in both iNOS KO and wild-type mice compared with saline-infused wild-type mice. Isoproterenol...

heart failure is a clinical syndrome characterized by the inability of the heart to provide nutrient supply to tissues. in 75% of cases, the underlying pathology causing heart failure in patients with cardiac death is coronary heart disease. a rabbit model of heart failure with coronary ligation was produced to mimic coronary heart disease in humans. after producing the model, two arteries and ...

Lysosomal acid hydrolases play an imperative part in the initiation of inflammation processes associated with myocardial infarction. In the present investigation, we have studied the protective effect of L-glutamine on isoproterenol-induced myocardial damage in male albino rats with respect to alterations in lysosomal function. The myocardial infarction in experimental animals was induced by in...